Zhang Chunlei, Chen Juan, Zhao Fang, Chen Ruoyun, Yu Dequan, Cao Zhengyu
State Key Laboratory of Natural Medicines & Jiangsu Provincial Key laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University, Nanjing, Jiangsu 211198, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Natural Medicines & Jiangsu Provincial Key laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
Fitoterapia. 2017 Oct;122:20-25. doi: 10.1016/j.fitote.2017.08.003. Epub 2017 Aug 12.
Iritectol G, a novel iridal-type triterpenoid containing an uncommon tetrahydrofuran moiety, was isolated from the rhizomes of Iris tectorum. The structure was elucidated by comprehensive spectroscopic analysis. Iritectol G inhibited spontaneous and 4-aminopyridine-evoked calcium oscillations in primary cultured neocortical neurons with IC values of 8.2μM and 12.5μM, respectively. Further electrophysiological study demonstrated that iritectol G preferred to interact with inactivated state of voltage-gated sodium channel with an IC value of 7.0μM. These data demonstrated that iritectol G was a novel sodium channel inhibitor.
鸢尾酮醇G是一种含有罕见四氢呋喃部分的新型鸢尾烷型三萜类化合物，从鸢尾的根茎中分离得到。通过综合光谱分析阐明了其结构。鸢尾酮醇G抑制原代培养的新皮质神经元中的自发和4-氨基吡啶诱发的钙振荡，其IC值分别为8.2μM和12.5μM。进一步的电生理研究表明，鸢尾酮醇G更倾向于与电压门控钠通道的失活状态相互作用，IC值为7.0μM。这些数据表明鸢尾酮醇G是一种新型的钠通道抑制剂。
