Department of Physiology, McGill Univesity, Bellini Life Sciences Bldg., Rm 166, 3649 Promenade Sir-William-Osler, Montreal, Quebec H3G 0B1, Canada.
Cell Res. 2017 Sep;27(9):1075-1076. doi: 10.1038/cr.2017.101. Epub 2017 Aug 15.
SMADs are essential transcriptional effectors of transforming growth factor-β (TGFβ)/TGFβ-related signaling that underlies embryonic development and adult homeostasis. A recent study by Fang et al. in Cell Research adds to this biological complexity by demonstrating an atypical cytoplasmic role for SMAD5 in modulating the bioenergetic homeostasis (i.e., glycolysis and mitochondrial respiration) of cells in response to fluctuations in intracellular pH that is independent of receptor signaling.
SMADs 是转化生长因子-β（TGFβ）/TGFβ 相关信号转导的重要转录效应因子，这些信号在胚胎发育和成人稳态中起着基础作用。最近，Fang 等人在《Cell Research》上的一项研究增加了这种生物学复杂性，证明了 SMAD5 在细胞质中发挥非典型作用，可调节细胞的生物能量稳态（即糖酵解和线粒体呼吸），以响应细胞内 pH 的波动，而这种作用与受体信号无关。
