Horst Diogo José, Tebcherani Sergio Mazurek, Kubaski Evaldo Toniolo, de Almeida Vieira Rogério
Federal University of Technology-Paraná, 84016-210 Ponta Grossa, PR, Brazil.
Department of Production Engineering, Federal University of Technology-Paraná, 84016-210 Ponta Grossa, PR, Brazil.
Bioinorg Chem Appl. 2017;2017:6398167. doi: 10.1155/2017/6398167. Epub 2017 Jul 25.
This experimental study investigates the bioactive potential of filaments produced via hot melt extrusion (HME) and intended for fused deposition modeling (FDM) 3D printing purposes. The oleo-gum-resins from benzoin, myrrha, and olibanum in pure state and also charged with 10% of metal oxide nanoparticles, TiO, P25, CuO, and MoO, were characterized by ultraviolet-visible (UV-Vis) and Fourier transform infrared (FTIR) spectroscopy, energy-dispersive X-ray microanalysis (EDXMA), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). Disks were 3D-printed into model geometries (10 × 5 mm) and the disk-diffusion methodology was used for the evaluation of antimicrobial and antifungal activity of materials in study against the clinical isolates: , and . Due to their intrinsic properties, disks containing resins in pure state mostly prevent surface-associated growth; meanwhile, disks loaded with 10% oxides prevent planktonic growth of microorganisms in the susceptibility assay. The microscopy analysis showed that part of nanoparticles was encapsulated by the biopolymeric matrix of resins, in most cases remaining disorderly dispersed over the surface of resins. Thermal analysis shows that plant resins have peculiar characteristics, with a thermal behavior similar to commercial available semicrystalline polymers, although their structure consists of a mix of organic compounds.
本实验研究调查了通过热熔挤出（HME）生产并用于熔融沉积建模（FDM）3D打印目的的长丝的生物活性潜力。对安息香、没药和乳香的纯态油胶树脂以及负载10%金属氧化物纳米颗粒（TiO、P25、CuO和MoO）的油胶树脂进行了紫外可见（UV-Vis）光谱、傅里叶变换红外（FTIR）光谱、能量色散X射线微分析（EDXMA）、扫描电子显微镜（SEM）和差示扫描量热法（DSC）表征。将圆盘3D打印成模型几何形状（10×5毫米），并采用圆盘扩散法评估研究材料对临床分离株、和的抗菌和抗真菌活性。由于其固有特性，纯态含树脂的圆盘大多能防止表面相关生长；同时，负载10%氧化物的圆盘在药敏试验中能防止微生物的浮游生长。显微镜分析表明，部分纳米颗粒被树脂的生物聚合物基质包裹，在大多数情况下，它们在树脂表面无序分散。热分析表明，植物树脂具有独特的特性，其热行为类似于市售的半结晶聚合物，尽管其结构由有机化合物混合而成。
