Hybrid core shell nanoparticles entrapping Gd-DTPA and F-FDG for simultaneous PET/MRI acquisitions.

AIM

Although there has been an improvement in the hardware and software of the PET/MRI system, the development of the nanoprobes exploiting the simultaneous acquisition of the bimodal data is still under investigation. Moreover, few studies on biocompatible and clinically relevant probes are available. This work presents a core-shell polymeric nanocarrier with improved relaxometric properties for simultaneous PET/MRI acquisitions.

MATERIALS & METHODS: Core-shell nanoparticles entrapping the Gd-DTPA and F-FDG are obtained by a complex coacervation.

RESULTS & DISCUSSION: The boosting of r of the entrapped Gd-DTPA up to five-times compared with 'free Gd-DTPA', is confirmed by the PET/MRI scan. The sorption of F-FDG into the nanoparticles is studied and designed to be integrated downstream for the production of the tracer.