Istituto Italiano di Tecnologia, Center for Advanced Biomaterials for Health Care IIT@CRIB, Largo Barsanti e Matteucci 53, 80125 Naples, Italy.
Department of Chemical, Materials & Industrial Production Engineering, University of Naples Federico II, P.le Tecchio 80, 80125 Naples, Italy.
Nanomedicine (Lond). 2017 Sep;12(18):2223-2231. doi: 10.2217/nnm-2017-0110. Epub 2017 Aug 17.
Although there has been an improvement in the hardware and software of the PET/MRI system, the development of the nanoprobes exploiting the simultaneous acquisition of the bimodal data is still under investigation. Moreover, few studies on biocompatible and clinically relevant probes are available. This work presents a core-shell polymeric nanocarrier with improved relaxometric properties for simultaneous PET/MRI acquisitions.
MATERIALS & METHODS: Core-shell nanoparticles entrapping the Gd-DTPA and F-FDG are obtained by a complex coacervation.
RESULTS & DISCUSSION: The boosting of r of the entrapped Gd-DTPA up to five-times compared with 'free Gd-DTPA', is confirmed by the PET/MRI scan. The sorption of F-FDG into the nanoparticles is studied and designed to be integrated downstream for the production of the tracer.
尽管 PET/MRI 系统的硬件和软件都有所改进，但同时获取双模数据的纳米探针的开发仍在研究中。此外，可用的生物相容性和临床相关探针很少。本工作提出了一种具有改进的弛豫性能的核壳聚合物纳米载体，可用于同时进行 PET/MRI 采集。
通过复凝聚法获得包埋 Gd-DTPA 和 F-FDG 的核壳纳米粒子。
通过 PET/MRI 扫描证实，包埋的 Gd-DTPA 的 r 值比“游离 Gd-DTPA”提高了五倍。研究了 F-FDG 被吸附到纳米粒子中，并设计将其整合到下游以生产示踪剂。
