de Ávila Berta Esteban-Fernández, Angsantikul Pavimol, Li Jinxing, Angel Lopez-Ramirez Miguel, Ramírez-Herrera Doris E, Thamphiwatana Soracha, Chen Chuanrui, Delezuk Jorge, Samakapiruk Richard, Ramez Valentin, Obonyo Marygorret, Zhang Liangfang, Wang Joseph
Department of NanoEngineering, University of California San Diego, La Jolla, CA, 92093, USA.
Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Nat Commun. 2017 Aug 16;8(1):272. doi: 10.1038/s41467-017-00309-w.
Advances in bioinspired design principles and nanomaterials have led to tremendous progress in autonomously moving synthetic nano/micromotors with diverse functionalities in different environments. However, a significant gap remains in moving nano/micromotors from test tubes to living organisms for treating diseases with high efficacy. Here we present the first, to our knowledge, in vivo therapeutic micromotors application for active drug delivery to treat gastric bacterial infection in a mouse model using clarithromycin as a model antibiotic and Helicobacter pylori infection as a model disease. The propulsion of drug-loaded magnesium micromotors in gastric media enables effective antibiotic delivery, leading to significant bacteria burden reduction in the mouse stomach compared with passive drug carriers, with no apparent toxicity. Moreover, while the drug-loaded micromotors reach similar therapeutic efficacy as the positive control of free drug plus proton pump inhibitor, the micromotors can function without proton pump inhibitors because of their built-in proton depletion function associated with their locomotion.Nano- and micromotors have been demonstrated in vitro for a range of applications. Here the authors demonstrate the in-vivo therapeutic use of micromotors to treat H. pylori infection.
受生物启发的设计原理和纳米材料的进展，已使具有不同功能的自主移动合成纳米/微米马达在不同环境中取得了巨大进展。然而，在将纳米/微米马达从试管转移到活生物体以高效治疗疾病方面，仍存在显著差距。在此，据我们所知，我们首次展示了体内治疗性微米马达在主动药物递送中的应用，该应用以克拉霉素作为模型抗生素，幽门螺杆菌感染作为模型疾病，用于治疗小鼠模型中的胃部细菌感染。载药镁微米马达在胃部介质中的推进能够实现有效的抗生素递送，与被动药物载体相比，可显著降低小鼠胃部的细菌负荷，且无明显毒性。此外，虽然载药微米马达达到了与游离药物加质子泵抑制剂阳性对照相似的治疗效果，但由于其与运动相关的内置质子消耗功能，微米马达无需质子泵抑制剂即可发挥作用。纳米和微米马达已在体外展示了一系列应用。本文作者展示了微米马达在治疗幽门螺杆菌感染方面的体内治疗用途。
