Institute of Biomedical Research, Shandong University of Technology , Zibo , Shandong , People's Republic of China.
Zibo Key Laboratory of New Drug Development of Neurodegenerative Diseases, Shandong University of Technology , Zibo , Shandong , People's Republic of China.
Crit Rev Food Sci Nutr. 2019;59(18):2896-2902. doi: 10.1080/10408398.2018.1478388. Epub 2018 Dec 30.
Curcumin is a polyphenolic compound with a long history of use as an herbal remedy, dietary spice, and food-coloring agent. Despite curcumin possesses a wide range of biological and pharmacological activities, it exhibits extremely poor bioavailability, which makes its pharmacology intriguing and also hinders its clinical application. In recent years, there is ample evidence supporting the associations between the alteration of gut microbiota and many diseases. Interestingly, after oral administration, curcumin shows its preferential distribution and accumulation in the intestine. In view of the above aspects, we reviewed the updated knowledge regarding the bidirectional interactions between curcumin and gut microbiota from two perspectives: (1) gut microbiota regulation by curcumin and (2) curcumin biotransformation by digestive microbiota. Besides the study deals with 3 potential pharmacological implications: (1) identification of metabolites being more active and bioavaliable than parent curcumin; (2) assessment of contribution of gut microbiota regulation of curcumin to its pharmacological effects and (3) development of gut microbiota regulation-based disease prevention/treatment strategy for curcumin in view of its clinical safety. This review is important to deepen our understanding of the mechanisms of action of curcumin and to provide future directions about how to use this natural compound to combat human diseases.
姜黄素是一种多酚化合物，具有作为草药疗法、膳食香料和食品着色剂的悠久历史。尽管姜黄素具有广泛的生物学和药理学活性，但它表现出极差的生物利用度，这使得其药理学引人入胜，同时也阻碍了其临床应用。近年来，有大量证据支持肠道微生物群的改变与许多疾病之间的关联。有趣的是，口服姜黄素后，它在肠道中表现出优先分布和积累。鉴于上述方面，我们从两个方面综述了姜黄素和肠道微生物群之间双向相互作用的最新知识：（1）姜黄素对肠道微生物群的调节，（2）消化微生物群对姜黄素的生物转化。除了这项研究还涉及 3 种潜在的药理学意义：（1）鉴定比母体姜黄素更活跃和生物利用度更高的代谢物；（2）评估姜黄素对其药理作用的肠道微生物群调节的贡献，以及（3）鉴于姜黄素的临床安全性，开发基于肠道微生物群调节的疾病预防/治疗策略。这篇综述对于加深我们对姜黄素作用机制的理解以及为如何利用这种天然化合物来对抗人类疾病提供未来方向非常重要。
