Institut für Physiologische Chemie, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany.
Nutrients. 2017 Aug 17;9(8):889. doi: 10.3390/nu9080889.
Therapeutic effects of continuous intravenous infusions of solvent-free low doses of resveratrol on organ injury and systemic consequences resulting from severe hemorrhagic shock in rats were studied. Hemorrhagic shock was induced by withdrawing arterial blood until a mean arterial blood pressure (MAP) of 25-30 mmHg was reached. Following a shock phase of 60 min, rats were resuscitated with the withdrawn blood plus lactated Ringer's. Resveratrol (20 or 60 μg/kg × h) was continuously infused intravenously starting with the resuscitation phase (30 min) and continued until the end of the experiment (total treatment time 180 min). Animals of the shock control group received 0.9% NaCl solution. After the observation phase (150 min), rats were sacrificed. Resveratrol significantly stabilized the MAP and peripheral oxygen saturation after hemorrhagic shock, decreased the macroscopic injury of the small intestine, significantly attenuated the shock-induced increase in tissue myeloperoxidase activity in the small intestine, liver, kidney and lung, and diminished tissue hemorrhages (particularly in the small intestine and liver) as well as the rate of hemolysis. Already very low doses of resveratrol, continuously infused during resuscitation after severe hemorrhagic shock, can significantly improve impaired systemic parameters and attenuate multiple organ damage in rats.
研究了无溶剂低剂量白藜芦醇持续静脉输注对大鼠严重失血性休克引起的器官损伤和全身后果的治疗作用。通过抽取动脉血将平均动脉血压（MAP）降至 25-30mmHg 来诱导失血性休克。在休克 60 分钟后，用抽出的血液和乳酸林格氏液进行复苏。从复苏阶段（30 分钟）开始，持续静脉输注白藜芦醇（20 或 60μg/kg×h），持续到实验结束（总治疗时间 180 分钟）。休克对照组的动物接受 0.9%生理盐水溶液。观察阶段（150 分钟）后，处死大鼠。白藜芦醇显著稳定了失血性休克后的平均动脉压和外周血氧饱和度，降低了小肠的宏观损伤，显著减弱了休克引起的小肠、肝、肾和肺组织髓过氧化物酶活性的增加，并减少了组织出血（尤其是小肠和肝脏）和溶血率。在严重失血性休克后复苏期间持续输注的非常低剂量的白藜芦醇，可显著改善受损的全身参数并减轻大鼠的多器官损伤。
