Schwarz S S, Freed W J
Exp Brain Res. 1987;65(2):449-54. doi: 10.1007/BF00236318.
Previous experiments have proven brain tissue transplantation effective in reversing lesion-induced behavioral deficits in mature rats. This study reversed the usual experimental paradigm, so that fetal substantia nigra was transplanted into intact neonatal rats and allowed to mature in the host brain. Upon maturation substantia nigra lesions were made bilaterally to reveal the functional contribution of the transplanted tissue. In control animals these lesions depleted striatal dopamine, producing rigidity, poverty of movement and abnormal posture comparable to Parkinson's disease in the human; cessation of feeding and drinking led to progressive weight loss and death. In contrast, fetal substantia nigra transplanted into the neonatal rat became well-integrated in the host brain and was shown to protect the animal from this syndrome produced by subsequent substantia nigra lesions. We suggest that transplantation in these neonatal rats was performed during a crucial period of synaptogenesis, an environment particularly favorable to host-transplant interaction.
先前的实验已证明，脑组织移植对于逆转成熟大鼠因损伤引起的行为缺陷有效。本研究颠倒了通常的实验模式，将胎龄黑质移植到完整的新生大鼠体内，并使其在宿主脑中成熟。待其成熟后，双侧制造黑质损伤，以揭示移植组织的功能作用。在对照动物中，这些损伤使纹状体多巴胺耗尽，产生类似于人类帕金森病的僵硬、运动减少和姿势异常；停止进食和饮水导致体重逐渐减轻并死亡。相比之下，移植到新生大鼠体内的胎龄黑质在宿主脑中整合良好，并显示出能保护动物免受后续黑质损伤所产生的这种综合征的影响。我们认为，在这些新生大鼠中进行移植是在突触形成的关键时期进行的，这是一个特别有利于宿主与移植组织相互作用的环境。
