Dunnett S B, Björklund A, Schmidt R H, Stenevi U, Iversen S D
Acta Physiol Scand Suppl. 1983;522:39-47.
Bilateral 6-hydroxydopamine-induced lesions of the ascending forebrain dopamine neurones induce a behavioural syndrome in rats which includes profound aphagia, adipsia, akinesia and bilateral sensorimotor neglect. Such animals will die unless maintained by intragastric feeding. Three experiments are reported in which we have attempted to ameliorate this syndrome with single or multiple placements of nigral cell suspensions into the forebrains of rats with bilateral dopamine depletions. Although the grafts were efficient in reversing the sensorimotor and akinetic impairments, and produced a significant increase in eating, the grafted rats remained hypophagic and adipsic. The results indicate that although many components of the bilateral dopamine denervation syndrome can be reversed by intrastriatal nigral suspension grafts, the severe eating and drinking deficits remain unameliorated.
双侧6-羟基多巴胺诱导的前脑多巴胺能神经元上行通路损伤会在大鼠中诱发一种行为综合征，该综合征包括严重的摄食减少、饮水减少、运动不能以及双侧感觉运动忽视。除非通过胃内喂养维持，否则此类动物将会死亡。本文报道了三项实验，在这些实验中，我们尝试通过将黑质细胞悬液单次或多次植入双侧多巴胺耗竭的大鼠前脑来改善这种综合征。尽管移植有效地逆转了感觉运动和运动不能障碍，并使进食量显著增加，但移植后的大鼠仍存在摄食减少和饮水减少的问题。结果表明，虽然纹状体内黑质悬液移植可以逆转双侧多巴胺去神经支配综合征的许多症状，但严重的进食和饮水缺陷仍未得到改善。
