Hepatogastroenterology Unit, Second Department of Internal Medicine - Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, ''Attikon" University General Hospital, Athens, Greece.
4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, ''Attikon" University General Hospital, Athens, Greece.
Med Hypotheses. 2017 Sep;106:26-32. doi: 10.1016/j.mehy.2017.07.005. Epub 2017 Jul 6.
Functional dyspepsia is a highly prevalent disease, with significant impacts on patients' quality of life and economic robustness of health care systems worldwide. It constitutes a constellation of symptoms located in the gastro duodenal region while its pathogenesis remains poorly understood. Accumulating evidence suggest that small intestinal bacterial overgrowth is associated with the etiology of functional gastrointestinal disorders. We herein present the hypothesis that a causal link between small intestinal bacterial overgrowth and functional dyspepsia might exist. Development of functional dyspepsia symptoms may derive from abnormal fermentation of carbohydrates due to increased proliferation of coliform bacteria, resulting in luminal distension, increased intestinal permeability and immune response perpetuation in predisposed hosts, secondary to an episode of infectious gastroenteritis. Moreover, the treatment of functional dyspepsia remains challenging and we explore the feasibility of innovative therapeutic modalities based on our hypothesis.
功能性消化不良是一种高发疾病，对患者的生活质量和全球卫生保健系统的经济稳健性都有重大影响。它是一组位于胃十二指肠区域的症状，但其发病机制仍不清楚。越来越多的证据表明，小肠细菌过度生长与功能性胃肠疾病的病因有关。我们在此提出假设，即小肠细菌过度生长与功能性消化不良之间可能存在因果关系。功能性消化不良症状的发展可能源于由于大肠埃希菌的过度增殖导致碳水化合物异常发酵，从而导致腔内扩张、肠道通透性增加和免疫反应持续存在，这在易患宿主中继发于感染性胃肠炎发作。此外，功能性消化不良的治疗仍然具有挑战性，我们根据我们的假设探索了创新治疗模式的可行性。
