Serquiña Anna K, Ziegelbauer Joseph M
National Institutes of Health, Bethesda, MD.
National Institutes of Health, Bethesda, MD
J Cell Biol. 2017 Sep 4;216(9):2611-2613. doi: 10.1083/jcb.201708077. Epub 2017 Aug 17.
Herpesvirus genomes exist and replicate as episomes inside the host cell nucleus during latent infection. Chiu et al. (2017. https://doi.org/10.1083/jcb.201702013) find that unlike Epstein-Barr virus, which partitions viral genomes faithfully during cell division, Kaposi's Sarcoma-associated herpesvirus clusters viral genomes into loci that are distributed unequally to daughter cells.
在潜伏感染期间,疱疹病毒基因组以附加体的形式存在于宿主细胞核内并进行复制。邱等人(2017年。https://doi.org/10.1083/jcb.201702013)发现,与在细胞分裂过程中能忠实地分配病毒基因组的爱泼斯坦-巴尔病毒不同,卡波西肉瘤相关疱疹病毒会将病毒基因组聚集到向子细胞不均匀分布的位点。