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强心苷铃兰毒苷以不依赖p53的方式抑制结肠癌细胞的生长。

The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner.

作者信息

Anderson Sarah E, Barton Christopher E

机构信息

Department of Biology, Belmont University, 1900 Belmont Boulevard, Nashville, TN 37211, USA.

出版信息

Mol Genet Metab Rep. 2017 Aug 7;13:42-45. doi: 10.1016/j.ymgmr.2017.07.011. eCollection 2017 Dec.

DOI:10.1016/j.ymgmr.2017.07.011
PMID:28819586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5548364/
Abstract

Cardiac glycosides are plant-derived molecules that have shown antiproliferative properties against cancer cells, though the mechanism of action is not completely understood. We show that one cardiac glycoside, convallatoxin, presents antiproliferative effects against colorectal cancer cells in culture and that the resulting cell death is independent of the p53 tumor suppressor. Our data suggest that convallatoxin may be useful in the treatment of cancers that harbor inactivating mutations in the p53 signaling pathway.

摘要

强心苷是一类源自植物的分子，已显示出对癌细胞的抗增殖特性，但其作用机制尚未完全明确。我们发现，一种强心苷——铃兰毒苷，对培养中的结肠癌细胞具有抗增殖作用，且由此导致的细胞死亡与p53肿瘤抑制因子无关。我们的数据表明，铃兰毒苷可能对治疗p53信号通路存在失活突变的癌症有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be2/5548364/5da45d20482b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be2/5548364/5da45d20482b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be2/5548364/5da45d20482b/gr1.jpg

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2
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3
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