慢性消耗病朊病毒株的出现与宿主范围扩大。
Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion.
作者信息
Herbst Allen, Velásquez Camilo Duque, Triscott Elizabeth, Aiken Judd M, McKenzie Debbie
出版信息
Emerg Infect Dis. 2017 Sep;23(9):1598-1600. doi: 10.3201/eid2309.161474.
Abstract
Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95, into mice resulted in infection. Thus, emergent CWD prion strains may have higher zoonotic potential than common strains.
摘要
人类和小鼠的朊病毒蛋白具有一种结构基序，该基序可调节对常见慢性消耗病（CWD）朊病毒株的抗性。一种新出现的CWD朊病毒株H95成功传播到小鼠体内并导致感染。因此，新出现的CWD朊病毒株可能比常见毒株具有更高的人畜共患病潜力。
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