Peters Jeffrey M
From the Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802
J Biol Chem. 2017 Aug 18;292(33):13902-13903. doi: 10.1074/jbc.H117.783860.
Energy homeostasis and oncogenic signaling are critical determinants of the growth of human liver cancer cells, providing a strong rationale to elucidate the regulatory mechanisms for these systems. A new study reports that loss of solute carrier family 13 member 5, which transports citrate across cell membranes, halts liver cancer cell growth by altering both energy production and mammalian target of rapamycin signaling in human liver cancer cell lines and in both an and model of liver tumors, suggesting a new target for liver cancer chemoprevention and/or chemotherapy.
能量稳态和致癌信号是人类肝癌细胞生长的关键决定因素，这为阐明这些系统的调节机制提供了有力的理论依据。一项新的研究报告称，溶质载体家族13成员5负责跨细胞膜转运柠檬酸，其缺失通过改变人类肝癌细胞系以及两种肝癌模型中的能量产生和雷帕霉素哺乳动物靶标信号，从而使肝癌细胞生长停滞，这表明它是肝癌化学预防和/或化疗的一个新靶点。
