Mintaimycins，一种来自 sp. C-3509 的新型肽类代谢物。
Mintaimycins, a Group of Novel Peptide Metabolites from sp. C-3509.
机构信息
NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
出版信息
Molecules. 2022 Feb 9;27(4):1150. doi: 10.3390/molecules27041150.
A group of peptide metabolites (-), designated as mintaimycins, were isolated from sp. C-3509. The planar structures of mintaimycins were determined by combination of mass spectrometry, 1D and 2D NMR spectroscopy, and the stereochemistry of mintaimycins were partially resolved by Marfey's or Mosher's method. Mintaimycins featured a central -methylphenylalanine or phenylalanine linked at its amino group with 5-methyl-2-hexenoic acid, and at its carboxyl group with 5-hydroxy-norleucine or leucine that combined a derivative of hexanoic acid or 4-methylpentanoic acid. Mintaimycin A (), the principal component, was found to exhibit the biological activity of inducing pre-adipocyte differentiation of 3T3-L1 fibroblast cells at 10.0 μmol/L.
从 sp. C-3509 中分离得到一组肽代谢物 (-)，命名为薄荷霉素。通过质谱、1D 和 2D NMR 光谱学的组合，确定了薄荷霉素的平面结构，并且通过 Marfey 或 Mosher 方法部分解析了薄荷霉素的立体化学。薄荷霉素的特征是中央 -甲基苯丙氨酸或苯丙氨酸在其氨基上与 5-甲基-2-己烯酸相连，在其羧基上与 5-羟基-正亮氨酸或亮氨酸相连，亮氨酸结合了己酸或 4-甲基戊酸的衍生物。主要成分薄荷霉素 A () 被发现具有在 10.0 μmol/L 时诱导 3T3-L1 成纤维细胞前脂肪细胞分化的生物活性。
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