Liu Yunpeng, Wen Liuqing, Li Lei, Gadi Madhusudhan Reddy, Guan Wanyi, Huang Kenneth, Xiao Zhongying, Wei Mohui, Ma Cheng, Zhang Qing, Yu Hai, Chen Xi, Wang Peng George, Fang Junqiang
National Glycoengineering Research Center, Shandong Provincial Key Lab of Carbohydrate Chemistry, and State Key Lab of Microbial Technology, Shandong University, Jinan, Shandong 250100, People's Republic of China.
Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA, http://lithium.gsu.edu/faculty/PWang/.
European J Org Chem. 2016 Sep;2016(25):4315-4320. doi: 10.1002/ejoc.201600950. Epub 2016 Aug 16.
A concise, prototypical, and stereoselective strategy for the synthesis of therapeutically and immunologically significant glycosphingolipids has been developed. This strategy provides a universal platform for glycosphingolipid synthesis by block coupling of enzymatically prepared free oligosaccharideglycans to lipids using glycosyl -phenyltrifluoroacetimidates as efficient activated intermediates. As demonstrated here, two different types of glycosphingolipids were obtained in excellent yields using the method.
已经开发出一种简洁、典型且立体选择性的策略来合成具有治疗和免疫意义的糖鞘脂。该策略通过使用糖基-苯基三氟乙酰亚胺酯作为高效活化中间体，将酶促制备的游离寡糖聚糖与脂质进行片段偶联，为糖鞘脂合成提供了一个通用平台。如此处所示，使用该方法以优异的产率获得了两种不同类型的糖鞘脂。
