Hu Xiao, Liu Zhaomin, Chen Wen, Zheng Jun, Su Ningxin, Wang Wenjing, Lin Chongde, Luo Liang
Collaborative Innovation Center of Assessment Toward Basic Education Quality, Beijing Normal UniversityBeijing, China.
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal UniversityBeijing, China.
Front Hum Neurosci. 2017 Aug 2;11:399. doi: 10.3389/fnhum.2017.00399. eCollection 2017.
The judgment of learning (JOL) is an important form of prospective metamemory judgment, and the biological basis of the JOL process is an important topic in metamemory research. Although previous task-related functional magnetic resonance imaging (MRI) studies have examined the brain regions underlying the JOL process, the neural correlates of individual differences in JOL accuracy require further investigation. This study used structural and resting-state functional MRI to investigate whether individual differences in JOL accuracy are related to the gray matter (GM) volume and functional connectivity of the bilateral insula and medial Brodmann area (BA) 11, which are assumed to be related to JOL accuracy. We found that individual differences in JOL accuracy were related to the GM volume of the left mid-insula and to the functional connectivity between the left mid-insula and various other regions, including the left superior parietal lobule/precuneus, bilateral inferior parietal lobule/intraparietal sulcus, right frontal pole and left parahippocampal gyrus/fusiform gyrus/cerebellum. Further analyses indicated that the functional connectivity related to individual differences in JOL accuracy could be divided into two factors and might support information integration and selective attention processes underlying accurate JOLs. In addition, individual differences in JOL accuracy were not related to the GM volume or functional connectivity of the medial BA 11. Our findings provide novel evidence for the role of the left mid-insula and its functional connectivity in the JOL process.
学习判断（JOL）是前瞻性元记忆判断的一种重要形式，JOL过程的生物学基础是元记忆研究中的一个重要课题。尽管先前与任务相关的功能磁共振成像（MRI）研究已经考察了JOL过程背后的脑区，但JOL准确性个体差异的神经关联仍需进一步研究。本研究使用结构和静息态功能MRI来探究JOL准确性的个体差异是否与双侧脑岛和内侧布罗德曼区（BA）11的灰质（GM）体积及功能连接有关，这些区域被认为与JOL准确性相关。我们发现，JOL准确性的个体差异与左中脑岛的GM体积以及左中脑岛与其他多个区域之间的功能连接有关，这些区域包括左上顶叶小叶/楔前叶、双侧下顶叶小叶/顶内沟、右额极以及左海马旁回/梭状回/小脑。进一步分析表明，与JOL准确性个体差异相关的功能连接可分为两个因素，可能支持准确JOL背后的信息整合和选择性注意过程。此外，JOL准确性的个体差异与内侧BA 11的GM体积或功能连接无关。我们的研究结果为左中脑岛及其功能连接在JOL过程中的作用提供了新的证据。
