Jia Leili, Xie Jing, Zhao Jiangyun, Cao Dekang, Liang Yuan, Hou Xuexin, Wang Ligui, Li Zhenjun
Institute of Disease Control and Prevention of Chinese People's Liberation ArmyBeijing, China.
Center for Disease Control and Prevention of Chinese People's Armed Police ForcesBeijing, China.
Front Cell Infect Microbiol. 2017 Aug 3;7:338. doi: 10.3389/fcimb.2017.00338. eCollection 2017.
Influenza virus infection remains one of the largest disease burdens on humans. Influenza-associated bacterial co-infections contribute to severe disease and mortality during pandemic and seasonal influenza episodes. The mechanisms of severe morbidity following influenza-bacteria co-infections mainly include failure of an antibacterial immune response and pathogen synergy. Moreover, failure to resume function and tolerance might be one of the main reasons for excessive mortality. In this review, recent advances in the study of mechanisms of severe disease, caused by bacterial co-infections following influenza virus pathogenesis, are summarized. Therefore, understanding the synergy between viruses and bacteria will facilitate the design of novel therapeutic approaches to prevent mortality associated with bacterial co-infections.
流感病毒感染仍然是人类面临的最大疾病负担之一。流感相关的细菌合并感染会在大流行和季节性流感发作期间导致严重疾病和死亡。流感与细菌合并感染后严重发病的机制主要包括抗菌免疫反应失败和病原体协同作用。此外，无法恢复功能和耐受性可能是高死亡率的主要原因之一。在本综述中，总结了流感病毒发病机制后细菌合并感染导致严重疾病机制研究的最新进展。因此，了解病毒与细菌之间的协同作用将有助于设计新的治疗方法，以预防与细菌合并感染相关的死亡。
