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多节段退行性颈椎间盘疾病手术治疗的混合解决方案

Hybrid Solutions for the Surgical Treatment of Multilevel Degenerative Cervical Disk Disease.

作者信息

König Stefan Alexander, Ranguis Sebastian, Spetzger Uwe

机构信息

Neurochirurgische Klinik, Klinikum Karlsruhe, Karlsruhe, Germany.

Department of Neurosurgery, Prince of Wales Hospital, Randwick, New South Wales, Australia.

出版信息

Surg J (N Y). 2015 Nov 19;1(1):e16-e22. doi: 10.1055/s-0035-1567876. eCollection 2015 Dec.

Abstract

In different stages of cervical degenerative disk disease, the combination of dynamic and nondynamic implants may be considered. The aim of this study was to investigate the applicability of criteria to assist decision making in these cases.  Thirty patients with spondylotic cervical radiculopathy and a coincidence of soft disk and hard disk herniation were surgically treated with a hybrid solution (combination of total disk replacement and cage fusion). The control group included 32 patients who underwent two-level cage fusion. Pre- and postoperative Japanese Orthopaedic Association (JOA) scores and range of motion (ROM) were compared.  Twenty-three patients underwent two-level hybrid solution and 7 underwent three-level treatment. The most frequent solution ( = 13) was a combination of a dynamic implant at C5-C6 and a nondynamic implant at C6-C7. The mean JOA score improved from 13.9 to 15.6 points after surgery (mean deviation [MD] 1.6, 95% confidence interval [CI] 2.1 to 1.2,  < 0.001). ROM showed a slight trend to increase (MD 0.8, 95% CI -0.9 to 2.6,  = 0.193). In the control group, the mean JOA score improved from 13.3 to 15.1 points after surgery (MD 1.4, 95% CI 2.1 to 1.2,  < 0.001). The comparison of the postoperative JOA scores and recovery rates between the hybrid treatment group and the control group did not show significant differences.  In cases of coincident soft and hard degenerative cervical disk disease at adjacent levels, the combination of a disk prosthesis and a nondynamic implant is a safe and effective treatment option and an alternative to multilevel fusion.

摘要

在颈椎间盘退变的不同阶段,可以考虑采用动态和非动态植入物相结合的方式。本研究的目的是探讨相关标准在这些病例中辅助决策的适用性。30例患有脊髓型颈椎病且合并软性椎间盘和硬性椎间盘突出的患者接受了混合治疗方案(全椎间盘置换与椎间融合器融合相结合)。对照组包括32例行双节段椎间融合术的患者。比较了术前和术后日本骨科协会(JOA)评分及活动度(ROM)。23例患者接受了双节段混合治疗方案,7例接受了三节段治疗。最常见的治疗方案(n = 13)是C5-C6节段采用动态植入物与C6-C7节段采用非动态植入物相结合。术后JOA评分平均从13.9分提高到15.6分(平均差值[MD] 1.6,95%置信区间[CI] 2.1至1.2,P < 0.001)。ROM呈轻微增加趋势(MD 0.8,95% CI -0.9至2.6,P = 0.193)。对照组术后JOA评分平均从13.3分提高到15.1分(MD 1.4,95% CI 2.1至1.2,P < 0.001)。混合治疗组与对照组术后JOA评分及恢复率的比较未显示出显著差异。在相邻节段软性和硬性颈椎间盘退变合并的病例中,椎间盘假体与非动态植入物相结合是一种安全有效的治疗选择,也是多节段融合的替代方案。

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