Jo Kyungae, Jeon SangDuk, Ahn Chang-Won, Han Sung Hee, Suh Hyung Joo
Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul 02841, Korea.
Research and Development Center, Nong Shim Co., Ltd., Seoul 07057, Korea.
Prev Nutr Food Sci. 2017 Dec;22(4):293-299. doi: 10.3746/pnf.2017.22.4.293. Epub 2017 Dec 31.
We evaluated the sleep enhancement activity of the medicinal herbs valerian (), jujube (), lotus seed (), , , and baekbokryung (), which can relieve insomnia in a model. Locomotor activity was measured in the model to evaluate the sleep activity of Korean medicinal herbs traditionally used as sleep aids. The group treated with lotus seed extract showed less nocturnal activity. Treatment with 10 or 20 mg/mL of significantly reduced nocturnal activity compared to the control group (<0.05). The activity and sleep bouts of fruit flies were significantly decreased by a high-dose treatment (10 mg/mL) of lotus or extracts at night. Caffeine-treated showed increased nocturnal activity and decreased total sleep time (<0.05). Flies receiving the 10 mg-doses of lotus seed or extract showed significantly different nocturnal locomotor activity and total sleep time compared to caffeine-treated Lotus seed and extracts are attractive and valuable sleep-potentiating nutraceuticals.
我们评估了缬草、枣、莲子等草药的助眠活性，这些草药在某模型中可缓解失眠。在该模型中测量运动活性，以评估传统上用作助眠剂的韩药的助眠活性。用莲子提取物处理的组夜间活动较少。与对照组相比，用10或20mg/mL的[未明确的物质]处理可显著降低夜间活动（<0.05）。夜间高剂量（10mg/mL）的莲子或[未明确的物质]提取物处理显著降低了果蝇的活动和睡眠时长。咖啡因处理的果蝇夜间活动增加，总睡眠时间减少（<0.05）。接受10mg剂量莲子或[未明确的物质]提取物的果蝇与咖啡因处理的果蝇相比，夜间运动活性和总睡眠时间有显著差异。莲子和[未明确的物质]提取物是有吸引力且有价值的助眠营养保健品。
