Changes in Sleep-Wake Behavior Due to Lotus () Seed and Hwang Jeong () Extracts.

We evaluated the sleep enhancement activity of the medicinal herbs valerian (), jujube (), lotus seed (), , , and baekbokryung (), which can relieve insomnia in a model. Locomotor activity was measured in the model to evaluate the sleep activity of Korean medicinal herbs traditionally used as sleep aids. The group treated with lotus seed extract showed less nocturnal activity. Treatment with 10 or 20 mg/mL of significantly reduced nocturnal activity compared to the control group (<0.05). The activity and sleep bouts of fruit flies were significantly decreased by a high-dose treatment (10 mg/mL) of lotus or extracts at night. Caffeine-treated showed increased nocturnal activity and decreased total sleep time (<0.05). Flies receiving the 10 mg-doses of lotus seed or extract showed significantly different nocturnal locomotor activity and total sleep time compared to caffeine-treated Lotus seed and extracts are attractive and valuable sleep-potentiating nutraceuticals.