Farvardin Majid, Heidary Fatemeh, Sayehmiri Kourosh, Gharebaghi Reza, Jabbarvand Behrooz Mahmoud
Poostchi Eye Research Center, Dept. of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Public Health. 2017 Jun;46(6):724-732.
Glaucoma is the major ophthalmic public health issue and a leading basis of blindness. Elevated intraocular pressure (IOP) is still a foremost risk factor in development and progression of glaucoma. Central corneal thickness (CCT) may play as the risk factor for the progression of glaucoma, closely associated with IOP especially in pediatric age group. This study performed a pioneering investigation combining the outcomes of multiple studies using a meta-analytic approach.
Nineteen published articles between 1980 and 2015 were designated by searching Scopus, PubMed, and Google Scholar and analyzed with random effects model while I statistics employed to find out heterogeneity. Subsequently, the information statistically analyzed by Stata software ver. 11.20.
The mean IOP has been documented to 16.22 mmHg (95% CI: 15.48-16.97) in all races subgroups. Analyzing the data by race-based subgroups revealed the lowest IOP of 12.02 mmHg (95% CI: 11.40-12.64) in Indian children while IOP of 17.38 mmHg (95% CI: 15.77-18.98) documented in black children as the highest measurement. The mean CCT was 553.69 micrometer (95% CI: 551.60-555.78) among all races. Lowest CCT of 536.60 mm (95% CI: 531.82-541.38) has been documented in mixed Malay-Indian children whereas Chinese children ought to the highest CCT value of 557.68 mm (95% CI: 553.10-562.25).
Findings of published studies were inconsistent when considered independently; however, meta-analysis of these results showed a significant correlation between CCT and IOP. Owing to non-uniform methods used to measure IOP and CCT in studies, data were stratified into various subgroups according to the instruments used to measure IOP and CCT.
青光眼是主要的眼科公共卫生问题，也是致盲的主要原因。眼压升高仍然是青光眼发生和发展的首要危险因素。中央角膜厚度（CCT）可能是青光眼进展的危险因素，尤其在儿童年龄组中与眼压密切相关。本研究采用荟萃分析方法，对多项研究结果进行了开创性调查。
通过检索Scopus、PubMed和谷歌学术，选定了1980年至2015年间发表的19篇文章，并采用随机效应模型进行分析，同时使用I统计量来发现异质性。随后，用Stata软件11.20版对信息进行统计分析。
在所有种族亚组中，平均眼压记录为16.22 mmHg（95%可信区间：15.48 - 16.97）。按种族亚组分析数据显示，印度儿童的眼压最低，为12.02 mmHg（95%可信区间：11.40 - 12.64），而黑人儿童的眼压最高，记录为17.38 mmHg（95%可信区间：15.77 - 18.98）。所有种族的平均CCT为553.69微米（95%可信区间：551.60 - 555.78）。马来 - 印度混血儿童的CCT最低，为536.60毫米（95%可信区间：531.82 - 541.38），而中国儿童的CCT最高，为557.68毫米（95%可信区间：553.10 - 562.25）。
单独考虑时，已发表研究的结果并不一致；然而，这些结果的荟萃分析显示CCT与眼压之间存在显著相关性。由于研究中测量眼压和CCT的方法不统一，根据用于测量眼压和CCT的仪器将数据分层为不同亚组。
