Graduate Program for Neuroscience, Boston University, Boston, MA 02215, USA.
Department of Psychological and Brain Sciences, Boston University, Boston, MA 02215, USA.
Neuroimage. 2017 Nov 15;162:362-372. doi: 10.1016/j.neuroimage.2017.08.020. Epub 2017 Aug 19.
Human frontal cortex is commonly described as being insensitive to sensory modality, however several recent studies cast doubt on this view. Our laboratory previously reported two visual-biased attention regions interleaved with two auditory-biased attention regions, bilaterally, within lateral frontal cortex. These regions selectively formed functional networks with posterior visual-biased and auditory-biased attention regions. Here, we conducted a series of functional connectivity analyses to validate and expand this analysis to 469 subjects from the Human Connectome Project (HCP). Functional connectivity analyses replicated the original findings and revealed a novel hemispheric connectivity bias. We also subdivided lateral frontal cortex into 21 thin-slice ROIs and observed bilateral patterns of spatially alternating visual-biased and auditory-biased attention network connectivity. Finally, we performed a correlation difference analysis that revealed five additional bilateral lateral frontal regions differentially connected to either the visual-biased or auditory-biased attention networks. These findings leverage the HCP dataset to demonstrate that sensory-biased attention networks may have widespread influence in lateral frontal cortical organization.
人类额叶皮层通常被描述为对感觉模态不敏感，但最近的几项研究对这一观点提出了质疑。我们实验室之前报告了两个视觉偏向注意区域，以及两个听觉偏向注意区域，在外侧额叶皮层中双侧交替出现。这些区域与后部视觉偏向和听觉偏向注意区域选择性地形成了功能网络。在这里，我们进行了一系列的功能连接分析，以验证并扩展这一分析到来自人类连接组计划（HCP）的 469 名受试者。功能连接分析复制了最初的发现，并揭示了一种新的半球连接偏好。我们还将外侧额叶皮层细分为 21 个薄切片 ROI，并观察到双侧空间交替的视觉偏向和听觉偏向注意网络连接模式。最后，我们进行了相关差异分析，发现了另外五个与视觉偏向或听觉偏向注意网络有差异连接的双侧外侧额叶区域。这些发现利用 HCP 数据集证明了感觉偏向注意网络可能在外侧额叶皮层组织中具有广泛的影响。
