Souto Filho João Tadeu Damian, de Andrade Alícia Souza, Ribeiro Felipe Mesquita, Alves Paola de Araujo Sardenberg, Simonini Virgínia Ribeiro Fernandes
Faculdade de Medicina de Campos, Campos dos Goytacazes, Rio de Janeiro, Brazil; Instituto Federal de Educação, Ciência e Tecnologia Fluminense, Campos dos Goytacazes, Rio de Janeiro, Brazil.
Faculdade de Medicina de Campos, Campos dos Goytacazes, Rio de Janeiro, Brazil.
Hematol Oncol Stem Cell Ther. 2018 Mar;11(1):25-29. doi: 10.1016/j.hemonc.2017.06.003. Epub 2017 Aug 16.
OBJECTIVE/BACKGROUND: Vitamin D has been increasingly recognized as an immunomodulatory agent. Its deficiency has been associated with immune-mediated diseases such as asthma, rhinitis, and atopic dermatitis. These allergic conditions are dependent on T-helper type 2 (Th2) cells secreting interleukins, overproduction of immunoglobulin E (IgE), and eosinophil activation. We investigated the association between serum vitamin D levels and blood absolute eosinophil count.
We carried out a cross-sectional study of 669 men and women referred to a clinical pathology laboratory who underwent 25-hydroxyvitamin D testing and complete blood count analysis on the same day.
Vitamin D levels were stratified into four ranges: severely deficient (<10ng/mL), deficient (≥10ng/mL and <20ng/mL), insufficient (≥20ng/mL and <30ng/mL), or sufficient (≥30ng/mL). The mean/median eosinophil count in the four groups was 267/254cells/μL, 245/238cells/μL, 191/159cells/μL, and 182/146cells/μL, respectively, (p=.001). The difference was significant between the severe deficiency group and each of the other three groups (p=.012, p=.002, and p=.001, respectively). There was no statistical difference among the four groups in terms of total leukocyte counts (p=.151), neutrophils (p=.177), or lymphocytes (p=.582).
Vitamin D deficiency was associated with higher blood eosinophil count. These results support the possible role of vitamin D in the eosinophil immune response.
目的/背景：维生素D越来越被认为是一种免疫调节因子。其缺乏与哮喘、鼻炎和特应性皮炎等免疫介导疾病有关。这些过敏性疾病依赖于分泌白细胞介素的2型辅助性T细胞（Th2）、免疫球蛋白E（IgE）的过度产生以及嗜酸性粒细胞的激活。我们研究了血清维生素D水平与血液嗜酸性粒细胞绝对计数之间的关联。
我们对669名前往临床病理实验室的男性和女性进行了一项横断面研究，这些人在同一天接受了25-羟基维生素D检测和全血细胞计数分析。
维生素D水平分为四个范围：严重缺乏（<10ng/mL）、缺乏（≥10ng/mL且<20ng/mL）、不足（≥20ng/mL且<30ng/mL）或充足（≥30ng/mL）。四组的平均/中位数嗜酸性粒细胞计数分别为267/254个细胞/μL、245/238个细胞/μL、191/159个细胞/μL和182/146个细胞/μL（p = 0.001）。严重缺乏组与其他三组中的每一组之间的差异均具有统计学意义（分别为p = 0.012、p = 0.002和p = 0.001）。四组在总白细胞计数（p = 0.151）、中性粒细胞（p = 0.177）或淋巴细胞（p = 0.582）方面没有统计学差异。
维生素D缺乏与血液嗜酸性粒细胞计数升高有关。这些结果支持了维生素D在嗜酸性粒细胞免疫反应中可能发挥的作用。
