. Programa de Pós-Graduação em Ciências da Saúde, Universidade Estadual de Londrina, Londrina (PR) Brasil.
. Laboratório de Pesquisa em Fisioterapia Pulmonar, Departamento de Fisioterapia, Universidade Estadual de Londrina, Londrina (PR) Brasil.
J Bras Pneumol. 2020 Nov 6;47(1):e20200279. doi: 10.36416/1806-3756/e20200279. eCollection 2020.
In this cross-sectional study, we investigated the relationship that levels of vitamin D had with eosinophil counts and IgE levels in 26 children with asthma (6-12 years of age) in the city of Londrina, Brazil. Vitamin D levels were found to correlate significantly, albeit moderately, with age (r = -0.51) and eosinophilia (r = -0.49), although not with IgE levels (r = -0.12). When we stratified the sample into two groups by the median vitamin D level (< or ≥ 24 ng/mL), we found that those in the < 24 ng/mL group were older, had higher eosinophil counts, and had higher IgE levels. To our knowledge, this is the first study to show an association between low levels of vitamin D and more pronounced eosinophilia in children with asthma in Brazil.
在这项横断面研究中，我们调查了巴西隆德里纳市 26 名哮喘儿童（6-12 岁）体内维生素 D 水平与嗜酸性粒细胞计数和 IgE 水平之间的关系。研究发现，维生素 D 水平与年龄（r = -0.51）和嗜酸性粒细胞增多症（r = -0.49）有显著相关性，但与 IgE 水平（r = -0.12）无相关性。当我们按维生素 D 中位数（< 或 ≥ 24ng/mL）将样本分为两组时，我们发现维生素 D 水平 < 24ng/mL 的组年龄较大，嗜酸性粒细胞计数较高，IgE 水平也较高。据我们所知，这是第一项表明巴西哮喘儿童维生素 D 水平低与嗜酸性粒细胞增多症更明显相关的研究。
