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21 世纪的迷幻复兴:在大象的背上迈出英勇的步伐。

The 21st century psychedelic renaissance: heroic steps forward on the back of an elephant.

机构信息

Consultant Child and Adolescent and Addictions Psychiatrist Imperial College, London, UK.

出版信息

Psychopharmacology (Berl). 2018 Feb;235(2):551-560. doi: 10.1007/s00213-017-4713-7. Epub 2017 Aug 23.

DOI:10.1007/s00213-017-4713-7
PMID:28831571
Abstract

Given the plethora of new studies and published papers in the scientific press and the increasingly emerging presence of articles about positive psychedelic experiences appearing in the popular media, there is little doubt that we are in the midst of a Psychedelic Renaissance. The classical psychedelic drugs LSD and psilocybin and the entactogen MDMA are showing promise as tools to assist psychotherapy for a wide range of mental disorders, with multiple pilot studies demonstrating their safety and efficacy. In this article, the author describes how MDMA in particular has inherent characteristics that make it well suited for assisting trauma-focused psychotherapy in a population of patients who have experienced child abuse. But despite these advances, there remain many obstacles ahead of the widespread mainstream acceptance of psychedelic medicines. The author argues that the Misuse of Drugs Act 1971 is one such obstacle. Other impediments include a prevailing attitude of pseudoscience and rigidity from within the non-scientific psychedelic community itself. Resolution of these conflicts must be sought if medicine and society are to see psychedelics gaining a place in mainstream culture and science.

摘要

鉴于科学出版物中大量新的研究和已发表的论文,以及越来越多关于积极迷幻体验的文章出现在大众媒体上,毫无疑问,我们正处于迷幻文艺复兴时期。经典迷幻药 LSD 和裸盖菇素以及致幻剂 MDMA 作为辅助各种精神障碍心理治疗的工具显示出前景,多项试点研究证明了它们的安全性和有效性。在本文中,作者描述了 MDMA 如何具有内在特征,使其非常适合在经历过儿童虐待的患者群体中辅助以创伤为重点的心理治疗。但尽管取得了这些进展,迷幻药物要被广泛接受仍面临许多障碍。作者认为,1971 年《滥用药物法》就是这样一个障碍。其他障碍包括非科学迷幻界本身内部普遍存在的伪科学和僵化态度。如果医学和社会希望迷幻剂在主流文化和科学中占有一席之地,就必须解决这些冲突。

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本文引用的文献

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Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial.裸盖菇素可使患有危及生命癌症的患者的抑郁和焦虑症状大幅且持续减轻:一项随机双盲试验。
J Psychopharmacol. 2016 Dec;30(12):1181-1197. doi: 10.1177/0269881116675513.
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Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial.裸盖菇素治疗危及生命的癌症患者焦虑和抑郁后症状快速且持续缓解:一项随机对照试验
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基于德国不同社会人口群体的迷幻剂使用不同剂量类型的人群估计。
Sci Rep. 2025 May 29;15(1):18952. doi: 10.1038/s41598-025-03873-0.
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Psychedelic iatrogenic structural dissociation: an exploratory hypothesis on dissociative risks in psychedelic use.致幻性医源性结构性解离:关于致幻剂使用中解离风险的探索性假设。
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Psychedelics and the treatment of eating disorders: considerations for future research and practice.迷幻剂与饮食失调的治疗:对未来研究与实践的思考
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