Gaspar Ricardo, Pinto Luís Abegão, Sousa David Cordeiro
Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Vision Sciences Study Center, Faculdade de Medicina, Universidade de Lisboa, Portugal.
Arq Bras Oftalmol. 2017 Jun;80(3):202-206. doi: 10.5935/0004-2749.20170050.
Studies have suggested that corneal biomechanical properties influence intraocular pressure (IOP) measurements, namely central corneal thickness (CCT) and corneal hysteresis (CH). The present study aimed to investigate the associations of CH and CCT with glaucoma development.
We performed a review of the literature and meta-analysis of observational studies (2006-2016) that included both adult glaucoma patients and controls and reported CCT and CH as outcomes. Nineteen studies were conside red eligible, and the mean difference (MD) between groups (patient and control) for both variables was used for statistical analyses.
A total of 1,213 glaucoma and 1,055 healthy eyes were studied. Quan titative analysis suggested that CH was significantly lower in the glaucoma group than in the control group (MD=-1.54 mmHg, 95% CI [-1.68, -1.41], P<0.0001). Additionally, CCT was significantly lower in the glaucoma group than in the control group (MD=-8.49 µm, 95% CI [-11.36, -5.62], P<0.001).
Corneal properties appear to differ between glaucoma patients and healthy controls. Our results emphasize the importance of corneal biomechanical properties in IOP interpretation and should support further studies on the influence of CH and CCT in glaucoma screening and diagnosis.
研究表明角膜生物力学特性会影响眼压（IOP）测量，即中央角膜厚度（CCT）和角膜滞后量（CH）。本研究旨在探讨CH和CCT与青光眼发生之间的关联。
我们对2006年至2016年的观察性研究进行了文献综述和荟萃分析，这些研究纳入了成年青光眼患者和对照组，并将CCT和CH作为研究结果进行报告。共有19项研究被认为符合条件，两组（患者组和对照组）这两个变量的平均差异（MD）用于统计分析。
共研究了1213只青光眼患眼和1055只健康眼。定量分析表明，青光眼组的CH显著低于对照组（MD = -1.54 mmHg，95% CI [-1.68, -1.41]，P < 0.0001）。此外，青光眼组的CCT也显著低于对照组（MD = -8.49 µm，95% CI [-11.36, -5.62]，P < 0.001）。
青光眼患者与健康对照组的角膜特性似乎存在差异。我们的结果强调了角膜生物力学特性在眼压解读中的重要性，并应支持进一步研究CH和CCT在青光眼筛查和诊断中的影响。
