Nazarabadi Parivash Najafi, Etemad Zaher, Hoseini Rastegar, Moradi Fatah
Department of Physical Education and Sport Science, Sanandaj Branch, Islamic Azad University, Sunanda, Iran.
Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
Int J Prev Med. 2022 Apr 8;13:60. doi: 10.4103/ijpvm.IJPVM_312_20. eCollection 2022.
Inflammatory markers of blood are critical predictors of chronic diseases as well as exacerbating risk factors. Exercise is a well-known strategy to reduce the risk of inflammation and chronic disease. The present study aimed to investigate the anti-inflammatory effects of a period of aerobic training and vitamin D supplementation (AT + Vit D) in postmenopausal women with metabolic syndrome.
This quasi-experimental research was performed on forty-six patients with metabolic syndrome who were selected according to the available sampling method, and were randomly divided into four groups: AT + Vit D (50,000 IU), AT, Vit D (50,000 IU), and control (C). The training protocol consisted of 40-60 min of AT 60-75% of maximal heart rate, three times a week, for 8 weeks. One-way Analysis of variance (ANOVA) and -test were used to compare the between and within groups; the Bonferroni test was used if significant differences were found.
The combination of exercise and vitamin D significantly reduced C-reactive protein (CRP) ( = 0.001), interleukin-6 (IL-6) ( = 0.001), and improved the metabolic syndrome indices ( = 0.001 in all indices). The results also show that the improvement in the metabolic syndrome indices, CRP, and IL-6 was more significant in AT + Vit D, compared to AT or Vit D alone.
The findings from the present study suggested that a sedentary lifestyle and vitamin D deficiency accelerated the occurrence of metabolic syndrome probably by increasing the anti-inflammatory. Additionally, adequate levels of plasma vitamin D are necessary to achieve the beneficial metabolic effects of AT.
血液中的炎症标志物是慢性疾病的关键预测指标，也是加剧风险的因素。运动是一种众所周知的降低炎症和慢性疾病风险的策略。本研究旨在调查一段时期的有氧训练和补充维生素D（AT + Vit D）对患有代谢综合征的绝经后女性的抗炎作用。
本准实验研究对46名代谢综合征患者进行，这些患者根据便利抽样法选取，并随机分为四组：AT + Vit D（50,000国际单位）组、AT组、Vit D（50,000国际单位）组和对照组（C）。训练方案包括每周三次，每次40 - 60分钟的有氧训练，运动强度为最大心率的60 - 75%，持续8周。采用单因素方差分析（ANOVA）和t检验比较组间和组内差异；若发现显著差异，则使用Bonferroni检验。
运动和维生素D的联合使用显著降低了C反应蛋白（CRP）（P = 0.001）、白细胞介素 - 6（IL - 6）（P = 0.001），并改善了代谢综合征指标（所有指标P = 0.001）。结果还表明，与单独的AT或Vit D相比，AT + Vit D组在代谢综合征指标、CRP和IL - 6方面的改善更为显著。
本研究结果表明，久坐不动的生活方式和维生素D缺乏可能通过增加抗炎作用加速代谢综合征的发生。此外，充足的血浆维生素D水平对于实现有氧训练的有益代谢作用是必要的。
