Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
Acta Physiol (Oxf). 2018 Feb;222(2). doi: 10.1111/apha.12948. Epub 2017 Sep 16.
This study tested the hypothesis that high doses of anti-inflammatory drugs would attenuate the adaptive response to resistance training compared with low doses.
Healthy men and women (aged 18-35 years) were randomly assigned to daily consumption of ibuprofen (IBU; 1200 mg; n = 15) or acetylsalicylic acid (ASA; 75 mg; n = 16) for 8 weeks. During this period, subjects completed supervised knee-extensor resistance training where one leg was subjected to training with maximal volitional effort in each repetition using a flywheel ergometer (FW), while the other leg performed conventional (work-matched across groups) weight-stack training (WS). Before and after training, muscle volume (MRI) and strength were assessed, and muscle biopsies were analysed for gene and protein expression of muscle growth regulators.
The increase in m. quadriceps volume was similar between FW and WS, yet was (averaged across legs) greater in ASA (7.5%) compared with IBU (3.7%, group difference 34 cm ; P = 0.029). In the WS leg, muscle strength improved similarly (11-20%) across groups. In the FW leg, increases (10-23%) in muscle strength were evident in both groups yet they were generally greater (interaction effects P < 0.05) for ASA compared with IBU. While our molecular analysis revealed several training effects, the only group interaction (P < 0.0001) arose from a downregulated mRNA expression of IL-6 in IBU.
Maximal over-the-counter doses of ibuprofen attenuate strength and muscle hypertrophic adaptations to 8 weeks of resistance training in young adults. Thus, young individuals using resistance training to maximize muscle growth or strength should avoid excessive intake of anti-inflammatory drugs.
本研究旨在验证以下假设，即高剂量抗炎药物会减弱对阻力训练的适应反应，与低剂量相比。
健康的男性和女性（年龄 18-35 岁）被随机分配每天服用布洛芬（IBU；1200mg；n=15）或乙酰水杨酸（ASA；75mg；n=16），持续 8 周。在此期间，受试者完成了监督下的膝关节伸肌阻力训练，其中一条腿使用飞轮测力计（FW）进行最大自愿努力的重复训练，而另一条腿进行常规（在组间匹配工作量）重量堆叠训练（WS）。在训练前后，评估肌肉体积（MRI）和力量，并分析肌肉活检以评估肌肉生长调节剂的基因和蛋白表达。
FW 和 WS 之间股四头肌体积的增加相似，但 ASA（7.5%）比 IBU（3.7%）更大（双腿平均值；组间差异 34cm；P=0.029）。在 WS 腿中，肌肉力量的提高在各组中相似（11-20%）。在 FW 腿中，两组均出现肌肉力量的增加（10-23%），但 ASA 组的增加通常更大（交互作用效应 P<0.05）。虽然我们的分子分析显示了多种训练效应，但唯一的组间相互作用（P<0.0001）来自于 IBU 中 IL-6 的 mRNA 表达下调。
最大剂量的非处方布洛芬减弱了年轻人 8 周阻力训练后的力量和肌肉肥大适应。因此，使用阻力训练来最大限度地增加肌肉生长或力量的年轻人应避免过度摄入抗炎药物。
