School of Chemical Engineering, ‡Department of Health Sciences and Technology, Samsung Advanced Institute for Health Science & Technology (SAIHST), and §Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University , Suwon 16419, Republic of Korea.
ACS Appl Mater Interfaces. 2017 Sep 20;9(37):31469-31477. doi: 10.1021/acsami.7b09083. Epub 2017 Sep 5.
Sub-100 nm colloidal mesoporous silica (CMS) nanoparticles are evaluated as an adhesive for hydrogels or biological tissues. Because the adhesion energy is proportional to the surface area of the nanoparticles, the CMS nanoparticles could provide a stronger adhesion between two hydrogels than the nonporous silica nanoparticles. In the case of 50 nm CMS nanoparticles with a pore diameter of 6.45 nm, the maximum adhesion energy was approximately 35.0 J/m at 3.0 wt %, whereas the 10 wt % nonporous silica nanoparticle solution showed only 7.0 J/m. Moreover, the CMS nanoparticle solution had an adhesion energy of 22.0 J/m at 0.3 wt %, which was 11 times higher than that of the nonporous nanoparticles at the same concentration. Moreover, these CMS nanoparticles are demonstrated for adhering incised skin tissues of mouse, resulting in rapid healing even at a lower nanoparticle concentration. Finally, the CMS nanoparticles had added benefit of quick degradation in biological media because of their porous structure, which may prevent unwanted accumulation in tissues.
亚 100nm 胶体介孔硅 (CMS) 纳米颗粒被评估为水凝胶或生物组织的黏合剂。由于黏附能与纳米颗粒的表面积成正比，CMS 纳米颗粒可以在两个水凝胶之间提供比无孔硅纳米颗粒更强的黏附力。对于孔直径为 6.45nm 的 50nmCMS 纳米颗粒，在 3wt%时最大黏附能约为 35.0J/m，而 10wt%无孔硅纳米颗粒溶液仅显示 7.0J/m。此外，CMS 纳米颗粒溶液在 0.3wt%时的黏附能为 22.0J/m，是相同浓度下无孔纳米颗粒的 11 倍。此外，这些 CMS 纳米颗粒被证明可以黏附在小鼠切开的皮肤组织上，即使在较低的纳米颗粒浓度下也能迅速愈合。最后，由于其多孔结构，CMS 纳米颗粒在生物介质中具有快速降解的附加益处，这可能防止其在组织中不必要的积累。
