2014年西班牙璃眼蜱中克里米亚-刚果出血热病毒的基因组特征分析
Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014.
作者信息
Cajimat Maria N B, Rodriguez Sergio E, Schuster Isolde U E, Swetnam Daniele M, Ksiazek Thomas G, Habela Miguel A, Negredo Ana Isabel, Estrada-Peña Agustín, Barrett Alan D T, Bente Dennis A
机构信息
1 Galveston National Laboratory, Department of Microbiology & Immunology, Institute for Human Infections and Immunity, University of Texas Medical Branch , Galveston, Texas.
2 Department of Pathology, University of Texas Medical Branch , Galveston, Texas.
出版信息
Vector Borne Zoonotic Dis. 2017 Oct;17(10):714-719. doi: 10.1089/vbz.2017.2190. Epub 2017 Aug 24.
Abstract
Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne disease caused by CCHF virus (CCHFV). Ticks in the genus Hyalomma are the main vectors and reservoirs of CCHFV. In Spain, CCHFV was first detected in Hyalomma ticks from Cáceres in 2010. Subsequently, two autochthonous CCHF cases were reported in August 2016. In this study, we describe the characterization of the CCHFV genome directly from Hyalomma lusitanicum collected in Cáceres in 2014. Phylogenetic analyses reveal a close relationship with clade III strains from West Africa, with an estimated divergence time of 50 years. The results of this work suggest that CCHFV has been circulating in Spain for some time, and most likely originated from West Africa.
摘要
克里米亚-刚果出血热（CCHF）是一种由克里米亚-刚果出血热病毒（CCHFV）引起的严重蜱传疾病。璃眼蜱属蜱类是CCHFV的主要传播媒介和储存宿主。2010年，在西班牙卡塞雷斯的璃眼蜱中首次检测到CCHFV。随后，2016年8月报告了两例本土CCHF病例。在本研究中，我们描述了直接从2014年在卡塞雷斯采集的葡萄牙璃眼蜱中获得的CCHFV基因组特征。系统发育分析显示，它与来自西非的第三进化枝菌株关系密切，估计分歧时间为50年。这项工作的结果表明，CCHFV已在西班牙传播了一段时间，很可能起源于西非。
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