Panayotova Elitsa, Papa Anna, Trifonova Iva, Christova Iva
Department of Microbiology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Ticks Tick Borne Dis. 2016 Jul;7(5):1024-1028. doi: 10.1016/j.ttbdis.2016.05.010. Epub 2016 May 24.
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne human viral disease with fatality rate up to 30%. Two genetic lineages of CCHF virus (CCHFV) are present in Europe - lineage Europe 1 which contains pathogenic CCHFV strains, and lineage Europe 2 consisting of AP92 and AP92-like strains. In order to investigate CCHFV distribution and potential risk for humans, ticks were collected from livestock in the five districts where CCHF cases have been reported in the last five years in Bulgaria. CCHFV lineage Europe 1 was detected in 39 of 623 Hyalomma marginatum ticks (6.3%; range per village 2.7-15.2%), while CCHFV lineage Europe 2 was detected for the first time in Bulgaria in 49 of 415 Rhipicephalus sanguineus sensu lato ticks (11.8%; range 0-58.3%). The present study shows that both Europe 1 and Europe 2 CCHFV lineages are present in Bulgaria. The pathogenic role of the AP92-like strains remains to be elucidated.
克里米亚-刚果出血热（CCHF）是一种由蜱传播的人类病毒性疾病，病死率高达30%。欧洲存在克里米亚-刚果出血热病毒（CCHFV）的两个遗传谱系——包含致病性CCHFV毒株的欧洲1谱系，以及由AP92和AP92样毒株组成的欧洲2谱系。为了调查CCHFV的分布情况及对人类的潜在风险，在保加利亚过去五年报告过CCHF病例的五个地区，从家畜身上采集了蜱虫。在623只边缘璃眼蜱中的39只（6.3%；每个村庄的范围为2.7%-15.2%）检测到CCHFV欧洲1谱系，而在415只血红扇头蜱（狭义）中的49只（11.8%；范围为0%-58.3%）首次在保加利亚检测到CCHFV欧洲2谱系。本研究表明保加利亚存在欧洲1和欧洲2两个CCHFV谱系。AP92样毒株的致病作用仍有待阐明。
