Toyomaki Atsuhito, Hashimoto Naoki, Kako Yuki, Murohashi Harumitsu, Kusumi Ichiro
Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Graduate School of Education, Hokkaido University, Sapporo, Hokkaido, Japan.
PLoS One. 2017 Aug 24;12(8):e0183792. doi: 10.1371/journal.pone.0183792. eCollection 2017.
Several studies of self-monitoring dysfunction in schizophrenia have focused on the sense of agency to motor action using behavioral and psychophysiological techniques. So far, no study has ever tried to investigate whether the sense of agency or causal attribution for external events produced by self-generated decision-making is abnormal in schizophrenia. The purpose of this study was to investigate neural responses to feedback information produced by self-generated or other-generated decision-making in a multiplayer gambling task using even-related potentials and electroencephalogram synchronization. We found that the late positive component and theta/alpha synchronization were increased in response to feedback information in the self-decision condition in normal controls, but that these responses were significantly decreased in patients with schizophrenia. These neural activities thus reflect the self-reference effect that affects the cognitive appraisal of external events following decision-making and their impairment in schizophrenia.
多项关于精神分裂症自我监测功能障碍的研究聚焦于运用行为和心理生理学技术来研究对运动行为的能动感。到目前为止，尚无研究试图探究在精神分裂症中，由自我生成的决策所产生的外部事件的能动感或因果归因是否异常。本研究的目的是使用事件相关电位和脑电图同步技术，在多人赌博任务中研究对自我生成或他人生成的决策所产生的反馈信息的神经反应。我们发现，在正常对照组中，自我决策条件下对反馈信息的反应，晚期正成分和θ/α同步性增强，但在精神分裂症患者中这些反应显著减弱。因此，这些神经活动反映了影响决策后对外部事件认知评估的自我参照效应及其在精神分裂症中的损害。
