肾母细胞瘤中母源11号染色体等位基因的非随机丢失。
Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.
作者信息
Schroeder W T, Chao L Y, Dao D D, Strong L C, Pathak S, Riccardi V, Lewis W H, Saunders G F
出版信息
Am J Hum Genet. 1987 May;40(5):413-20.
Abstract
A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and their parents indicate that alleles lost in the tumors are of maternal origin. These data suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is not random.
摘要
一系列用于11号染色体的基因探针已被用于研究与肾母细胞瘤发生相关的遗传事件。对5例肾母细胞瘤患者及其父母的DNA样本进行检测，这些患者的肿瘤显示11号染色体等位基因缺失，结果表明肿瘤中缺失的等位基因来自母方。这些数据表明，在这些肾母细胞瘤中丢失的11号染色体等位基因的亲本来源并非随机。
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