父亲职业与子代肾母细胞瘤
Paternal occupation and Wilms' tumour in offspring.
作者信息
Wilkins J R, Sinks T H
出版信息
J Epidemiol Community Health. 1984 Mar;38(1):7-11. doi: 10.1136/jech.38.1.7.
A case-control study was conducted to test the hypothesis that paternal occupation is a risk factor for Wilms' tumour in offspring. Occupations associated with exposure to lead (Pb) and to hydrocarbons were examined by computing odds ratios, all of which were greater than unity but not by a statistically significant margin. When painters were considered separately, children whose fathers had been so employed were six times more likely to develop Wilms' tumour than children whose fathers had other occupations. Like the results for the Pb and hydrocarbon related occupations, the estimated relative risk associated with painters did not reach statistical significance. Although these data require cautious interpretation because of the relatively small number of subjects, the results reported here are not wholly consistent with the results of the one previous study of paternal occupation and Wilms' tumour in offspring.
开展了一项病例对照研究，以检验父亲的职业是后代患肾母细胞瘤的危险因素这一假设。通过计算优势比来研究与接触铅（Pb）和碳氢化合物相关的职业，所有优势比均大于1，但未达到统计学显著水平。当单独考虑油漆工职业时，父亲从事该职业的孩子患肾母细胞瘤的可能性是父亲从事其他职业的孩子的6倍。与铅和碳氢化合物相关职业的结果一样，与油漆工相关的估计相对风险未达到统计学显著性。尽管由于受试者数量相对较少，这些数据需要谨慎解读，但此处报告的结果与之前一项关于父亲职业与后代肾母细胞瘤的研究结果并不完全一致。
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