饮食异黄酮摄入对缓解期溃疡性结肠炎个体胃肠道症状的影响。
Influence of dietary isoflavone intake on gastrointestinal symptoms in ulcerative colitis individuals in remission.
机构信息
Dominika Głąbska, Dominika Grudzińska, Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences (WULS-SGGW), 02-776 Warsaw, Poland.
出版信息
World J Gastroenterol. 2017 Aug 7;23(29):5356-5363. doi: 10.3748/wjg.v23.i29.5356.
AIM
To analyse the association between isoflavone intake and ulcerative colitis motility symptoms in individuals in remission.
METHODS
Cross-sectional study was conducted in a group of ulcerative colitis remission individuals, in sub-groups characterised by various intestinal motility and functioning characteristics (abdominal pain, flatulence, constipations, tenesmus). Total of 56 individuals with ulcerative colitis in remission (19 males and 37 females) were recruited for the study. Assessment of diet was based on self-reported data from each patient's dietary records taken over a period of three typical, random days (2 weekdays and 1 d of the weekend). The daily isoflavone intake (daidzein, genistein, glycitein and total isoflavones) and daily isoflavone intake per 1000 kcal of diet were assessed.
RESULTS
No correlations between isoflavone intake levels and number of bowel movements per day were observed both in the case of intake and intake per 1000 kcal of diet. In the group of individuals declaring lack of abdominal pain, the higher intakes of daidzein ( = 0.0075), daidzein per 1000 kcal of diet ( = 0.0358) and total isoflavone ( = 0.0358) were stated, than in the group of individuals declaring abdominal pain. In the group of individuals declaring lack of constipations, the lower intakes of glycitein ( = 0.0213) and glycitein per 1000 kcal of diet ( = 0.0213) were stated, than in the group of individuals declaring presence of constipations. No differences were observed in isoflavone intake between groups of ulcerative colitis individuals declaring lack of flatulence and declaring presence of flatulence, as well as between groups declaring lack of tenesmus and declaring presence of tenesmus.
CONCLUSION
The moderate dietary isoflavone intake may be beneficial for individuals with ulcerative colitis in remission, however, before including it into recommendations, further prospective studies are needed.
目的
分析在缓解期的个体中，异黄酮摄入与溃疡性结肠炎运动症状之间的关系。
方法
在溃疡性结肠炎缓解期个体中进行了一项横断面研究，根据不同的肠道运动和功能特征（腹痛、腹胀、便秘、里急后重）将个体分为亚组。共招募了 56 名溃疡性结肠炎缓解期患者（男性 19 名，女性 37 名）参与本研究。饮食评估基于每位患者在三个典型的随机日（2 个工作日和 1 个周末日）的饮食记录中的自我报告数据。评估了每日异黄酮摄入量（大豆苷、染料木黄酮、黄豆苷元和总异黄酮）和每 1000 千卡饮食中的异黄酮摄入量。
结果
无论是在摄入量还是每 1000 千卡饮食中的摄入量方面，都没有观察到异黄酮摄入量水平与每日排便次数之间的相关性。在没有腹痛的个体组中，大豆苷（ = 0.0075）、大豆苷每 1000 千卡饮食（ = 0.0358）和总异黄酮（ = 0.0358）的摄入量较高，而在有腹痛的个体组中则较低。在没有便秘的个体组中，黄豆苷元（ = 0.0213）和黄豆苷元每 1000 千卡饮食（ = 0.0213）的摄入量较低，而在有便秘的个体组中则较高。在没有腹胀的溃疡性结肠炎个体组和有腹胀的溃疡性结肠炎个体组之间，以及在没有里急后重的溃疡性结肠炎个体组和有里急后重的溃疡性结肠炎个体组之间，异黄酮的摄入量没有差异。
结论
适度的饮食异黄酮摄入可能对缓解期的溃疡性结肠炎患者有益，但在将其纳入建议之前，还需要进一步的前瞻性研究。
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