Chair of Dietetics, Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159c Nowoursynowska Str., 02-776 Warsaw, Poland.
Chair of Consumption Research, Department of Organization and Consumption Economics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159c Nowoursynowska Str., 02-776 Warsaw, Poland.
Nutrients. 2019 Aug 17;11(8):1936. doi: 10.3390/nu11081936.
Currently there are contradictory observations regarding the associations between the isoflavone intake and inflammatory bowel disease in terms of its prevention and treatment, and this may be attributed to the diversity of applied doses and influence of various isoflavones. The aim of the presented cross-sectional study is to analyze the association between intake of various isoflavones (daidzein, genistein, glicytein and total isoflavones) and ulcerative colitis symptoms (fecal blood, mucus and pus) in Polish Caucasian individuals in confirmed remission. Assessment of diet was based on self-reported data obtained from patients' three-day dietary records and their individual assessments of symptoms. A total of 56 Caucasian patients with ulcerative colitis in confirmed remission were recruited for the study (37 females and 19 males, aged 18-80). For individuals with no fecal mucus observed, higher daidzein ( = 0.035, 122 vs. 19 µg) and total isoflavone intakes ( = 0.034, 302.2 vs. 123.7 µg) were observed in comparison with individuals not declaring this symptom, while for daidzein it was confirmed for the component density of their diets. The opposite association was stated for fecal pus, as for individuals with a lack of this symptom, lower daidzein intake was stated in comparison with individuals declaring this symptom ( = 0.049, 103.3 vs. 206.7 µg), but it was not confirmed for the component density of the diets. It was stated that the high intake of isoflavones by Caucasian individuals, as in a western diet, may influence the symptoms of ulcerative colitis, with the strongest influence by daidzein. Taking this into account, isoflavones may be included into the diets of ulcerative colitis patients in remission if well-tolerated, but there is a need for further study.
目前，关于异黄酮的摄入与炎症性肠病的相关性存在相互矛盾的观察结果，无论是在预防还是治疗方面，这可能归因于应用剂量的多样性以及各种异黄酮的影响。本横断面研究的目的是分析波兰白种人群中各种异黄酮（大豆苷元、染料木黄酮、大豆苷和总异黄酮）的摄入量与溃疡性结肠炎症状（粪便中的血液、黏液和脓液）之间的关联，这些人群处于已确认的缓解期。饮食评估基于患者三天饮食记录和个体症状评估的自我报告数据。本研究共招募了 56 名处于已确认缓解期的溃疡性结肠炎白种人患者（37 名女性和 19 名男性，年龄 18-80 岁）。对于未观察到粪便黏液的个体，与未报告该症状的个体相比，其大豆苷元（ = 0.035，122 比 19 µg）和总异黄酮摄入量（ = 0.034，302.2 比 123.7 µg）更高，而对于大豆苷元，则是在饮食成分密度方面观察到了这种关联。对于粪便脓液则存在相反的关联，对于没有该症状的个体，与报告该症状的个体相比，其大豆苷的摄入量较低（ = 0.049，103.3 比 206.7 µg），但在饮食成分密度方面未得到证实。有研究表明，白种人高摄入异黄酮，就像西方饮食一样，可能会影响溃疡性结肠炎的症状，其中大豆苷的影响最强。考虑到这一点，如果异黄酮能被溃疡性结肠炎缓解期患者耐受，那么它们可以被纳入患者的饮食中，但需要进一步研究。
