Głąbska Dominika, Guzek Dominika, Gałązka Karolina, Lech Gustaw
Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), 159C Nowoursynowska Street, 02-787 Warsaw, Poland.
Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), 159C Nowoursynowska Street, 02-787 Warsaw, Poland.
J Clin Med. 2020 Mar 12;9(3):771. doi: 10.3390/jcm9030771.
A number of bioactive components of diet are indicated as potential dietary factors for the management of ulcerative colitis, while the recent study conducted in an animal model revealed that proanthocyanidins from grape seeds exert a broadly positive impact. The aim of the study was to verify the influence of dietary proanthocyanidins intake on the symptoms of ulcerative colitis in remission in human subjects. The study was conducted in a group of 55 participants (19 males, 36 females) in remission of ulcerative colitis confirmed based on both the Mayo Scoring system and Rachmilewitz index. Their habitual dietary intake of proanthocyanidins and intake recalculated per 1000 kcal of diet was assessed and it was verified whether they are associated with symptoms of ulcerative colitis. The energy value of diet and intake of other nutrients were analyzed as potential interfering factors. Participants declaring the presence of mucus in their stool compared with other participants were characterized by higher proanthocyanidins intake (142 vs. 75 mg; = 0.0441) and intake per 1000 kcal (91 vs. 37 mg/1000 kcal; = 0.0092), while for no other nutrient such association was stated. Participants declaring constipation compared with other participants were characterized by higher proanthocyanidins intake (214 vs. 82 mg; = 0.0289) and intake per 1000 kcal (118 vs. 41 mg/1000 kcal; = 0.0194). Similar association for constipation was observed in the case of energy value of diet and protein intake, but only for proanthocyanidins intake, it was confirmed in the logistic regression model ( = 0.0183; OR = 1.01; 95% CI 1.00-1.02). The positive influence of habitual dietary intake of proanthocyanidins was confirmed in the studied group of patients with ulcerative colitis in remission, as this intake may have increased the production of mucus, which is beneficial for intestinal healing, and may have reduced the frequency of bowel movements. However, further experimental human studies are necessary to confirm the potential influence of proanthocyanidins intake in patients with ulcerative colitis in remission.
饮食中的许多生物活性成分被认为是治疗溃疡性结肠炎的潜在饮食因素，而最近在动物模型中进行的研究表明，葡萄籽中的原花青素具有广泛的积极影响。本研究的目的是验证饮食中摄入原花青素对处于缓解期的人类溃疡性结肠炎症状的影响。该研究对一组55名参与者（19名男性，36名女性）进行，这些参与者基于梅奥评分系统和拉赫米列维茨指数被确诊为溃疡性结肠炎缓解期。评估了他们原花青素的习惯性饮食摄入量以及每1000千卡饮食重新计算后的摄入量，并验证它们是否与溃疡性结肠炎的症状相关。分析了饮食的能量值和其他营养素的摄入量作为潜在干扰因素。与其他参与者相比，宣称粪便中有黏液的参与者原花青素摄入量较高（142 vs. 75毫克；P = 0.0441），每1000千卡的摄入量也较高（91 vs. 37毫克/1000千卡；P = 0.0092），而对于其他营养素未发现这种关联。与其他参与者相比，宣称便秘的参与者原花青素摄入量较高（214 vs. 82毫克；P = 0.0289），每1000千卡的摄入量也较高（118 vs. 41毫克/1000千卡；P = 0.0194）。在饮食能量值和蛋白质摄入量方面，便秘也有类似关联，但只有原花青素摄入量在逻辑回归模型中得到证实（P = 0.0183；OR = 1.01；95% CI 1.00 - 1.02）。在研究的溃疡性结肠炎缓解期患者组中，证实了原花青素习惯性饮食摄入的积极影响，因为这种摄入可能增加了黏液的产生，这对肠道愈合有益，并且可能减少了排便频率。然而，需要进一步的人体实验研究来证实原花青素摄入对溃疡性结肠炎缓解期患者的潜在影响。
