Kumpf Oliver, Dohmen Pascal, Ertmer Martin, Knebel Fabian, Wiessner Alexandra, Kikhney Judith, Moter Annette, Treskatsch Sascha
Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité-University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Department of Cardiovascular Surgery, Campus Charité Mitte, Charité-University Medicine Berlin, Berlin, Germany.
Infection. 2016 Dec;44(6):813-817. doi: 10.1007/s15010-016-0916-9. Epub 2016 Jun 23.
We describe a case of Q-fever endocarditis with severe destruction of the aortic valve with perivalvular abscess formation and cardiac failure. The patient needed urgent operative treatment and postoperative critical care. All specimens sent for microbiological examination were negative. Molecular analysis, including fluorescence in situ hybridization of aortic valve tissue combined with PCR and sequencing, led to the correct diagnosis and to appropriate anti-infective treatment. The patient subsequently recovered from complex cardiovascular surgery. This is the first report on Q-fever endocarditis that was rapidly diagnosed using these methods.
我们描述了一例Q热心内膜炎病例，该病例伴有主动脉瓣严重破坏、瓣周脓肿形成及心力衰竭。患者需要紧急手术治疗及术后重症监护。所有送检进行微生物学检查的标本均为阴性。分子分析，包括主动脉瓣组织的荧光原位杂交结合PCR及测序，得出了正确诊断并给予了恰当的抗感染治疗。患者随后从复杂的心血管手术中康复。这是首例使用这些方法快速诊断Q热心内膜炎的报告。
