血糖稳态与糖尿病中的性别差异。
Gender differences in glucose homeostasis and diabetes.
作者信息
Mauvais-Jarvis Franck
机构信息
Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA, USA.
出版信息
Physiol Behav. 2018 Apr 1;187:20-23. doi: 10.1016/j.physbeh.2017.08.016. Epub 2017 Aug 24.
Abstract
Some aspects of glucose homeostasis are regulated differently in males and females. This review discusses the most fundamental gender differences in glucose homeostasis and diabetes. These include the prevalence of impaired fasting glucose and impaired glucose tolerance, the prevalence and incidence of type 2 and type 1 diabetes, and the sex-specific effects of testosterone and estrogen deficiency and excess. These gender-specific differences in glucose homeostasis represent a source of factors that should be studied to develop gender-based therapeutic avenues for diabetes.
摘要
葡萄糖稳态的某些方面在男性和女性中的调节方式有所不同。本综述讨论了葡萄糖稳态和糖尿病中最基本的性别差异。这些差异包括空腹血糖受损和葡萄糖耐量受损的患病率、2型和1型糖尿病的患病率和发病率，以及睾酮和雌激素缺乏与过量的性别特异性影响。葡萄糖稳态中的这些性别特异性差异是一系列因素的来源，应该对其进行研究，以开发针对糖尿病的性别特异性治疗途径。
相似文献
1
Gender differences in glucose homeostasis and diabetes.血糖稳态与糖尿病中的性别差异。
Physiol Behav. 2018 Apr 1;187:20-23. doi: 10.1016/j.physbeh.2017.08.016. Epub 2017 Aug 24.
2
Epidemiology of Gender Differences in Diabetes and Obesity.糖尿病和肥胖症中性别差异的流行病学。
Adv Exp Med Biol. 2017;1043:3-8. doi: 10.1007/978-3-319-70178-3_1.
3
Fasting glucose and increasing age.空腹血糖与年龄增长。
Diabetes Obes Metab. 2001 Aug;3(4):297-8. doi: 10.1046/j.1463-1326.2001.00135.x.
4
Increased risk of glomerular hyperfiltration in subjects with impaired glucose tolerance and newly diagnosed diabetes.糖耐量受损和新诊断糖尿病患者肾小球高滤过风险增加。
Nephrol Dial Transplant. 2016 Aug;31(8):1295-301. doi: 10.1093/ndt/gfv385. Epub 2015 Nov 25.
5
Comparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes.吡格列酮与二甲双胍对糖耐量受损和早期糖尿病患者胰岛素抵抗及激素指标影响的比较
Hypertens Res. 2007 Jan;30(1):23-30. doi: 10.1291/hypres.30.23.
6
Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired glucose tolerance.葡萄糖耐量受损的受试者对血糖浓度上升和下降的胰岛素分泌反应延迟。
Diabetologia. 2002 Apr;45(4):509-17. doi: 10.1007/s00125-002-0776-y.
7
Diabetes or impaired glucose tolerance: does the label matter?糖尿病或糖耐量受损：标签重要吗？
Diabetes Care. 2007 Dec;30(12):3029-30. doi: 10.2337/dc06-2379. Epub 2007 Aug 29.
8
9
Association of sleep time with diabetes mellitus and impaired glucose tolerance.睡眠时间与糖尿病及糖耐量受损的关联。
Arch Intern Med. 2005 Apr 25;165(8):863-7. doi: 10.1001/archinte.165.8.863.
10
High variability in oral glucose tolerance among 1,128 patients with cystic fibrosis: a multicenter screening study.1128例囊性纤维化患者口服葡萄糖耐量的高度变异性：一项多中心筛查研究。
PLoS One. 2014 Nov 13;9(11):e112578. doi: 10.1371/journal.pone.0112578. eCollection 2014.
引用本文的文献
1
The heterogeneity of youth at risk of prediabetes and diabetes: A latent class analysis of a United States national sample.糖尿病前期和糖尿病风险青年的异质性：美国全国样本的潜在类别分析。
Prev Med. 2025 Aug 7;199:108384. doi: 10.1016/j.ypmed.2025.108384.
2
Associations Between Shift Work and Insulin Resistance Markers in 53,053 Spanish Workers: A Sex-Stratified Cross-Sectional Analysis Using TyG, TyG-BMI, METS-IR, and SPISE-IR Indices.53053名西班牙工人的轮班工作与胰岛素抵抗标志物之间的关联：一项使用TyG、TyG-BMI、METS-IR和SPISE-IR指数的性别分层横断面分析
J Clin Med. 2025 Jun 29;14(13):4604. doi: 10.3390/jcm14134604.
3
Sex differences in resting skeletal muscle and the acute and long-term response to endurance exercise in individuals with overweight and obesity.超重和肥胖个体静息骨骼肌的性别差异以及对耐力运动的急性和长期反应。
Mol Metab. 2025 Aug;98:102185. doi: 10.1016/j.molmet.2025.102185. Epub 2025 Jun 16.
4
Exploring the Glycemic Control of Pay-for-Performance Program for Psychiatric Patients With Diabetes in Real World: A Retrospective Quasiexperimental Study.探索现实世界中糖尿病精神病患者绩效付费项目的血糖控制：一项回顾性准实验研究。
J Diabetes Res. 2025 Jun 4;2025:9660739. doi: 10.1155/jdr/9660739. eCollection 2025.
5
Epidemiology of Overweight and Obesity in Early Childhood in China and Associated Factors.中国幼儿超重与肥胖的流行病学及相关因素
Diabetes Metab Syndr Obes. 2025 May 29;18:1809-1822. doi: 10.2147/DMSO.S493135. eCollection 2025.
6
Development of Non-Invasive Continuous Glucose Prediction Models Using Multi-Modal Wearable Sensors in Free-Living Conditions.在自由生活条件下使用多模态可穿戴传感器开发无创连续血糖预测模型
Sensors (Basel). 2025 May 20;25(10):3207. doi: 10.3390/s25103207.
7
High-Fat Diet and Metabolic Diseases: A Comparative Analysis of Sex-Dependent Responses and Mechanisms.高脂饮食与代谢性疾病：性别依赖性反应及机制的比较分析
Int J Mol Sci. 2025 May 16;26(10):4777. doi: 10.3390/ijms26104777.
8
Early menopause in mothers and the risks of pre-diabetes and type 2 diabetes mellitus in female and male offspring: a population-based cohort study.母亲早绝经与子代患糖尿病前期及2型糖尿病的风险：一项基于人群的队列研究
Reprod Biol Endocrinol. 2025 May 22;23(1):76. doi: 10.1186/s12958-025-01405-z.
9
The Prevalence and Associated Factors of Impaired Fasting Glucose among Children and Adolescents in Urban China: A Large-Scale Cross-Sectional Study.中国城市儿童和青少年空腹血糖受损的患病率及相关因素：一项大规模横断面研究
Pediatr Diabetes. 2024 Mar 15;2024:6701192. doi: 10.1155/2024/6701192. eCollection 2024.
10
Sex Differences in Maturation and Function of Neonatal Porcine Islets Upon Transplantation in Mice.新生猪胰岛移植到小鼠体内后成熟及功能的性别差异
Xenotransplantation. 2025 Mar-Apr;32(2):e70039. doi: 10.1111/xen.70039.
本文引用的文献
1
Menopausal Hormone Therapy and Type 2 Diabetes Prevention: Evidence, Mechanisms, and Clinical Implications.更年期激素治疗与2型糖尿病预防：证据、机制及临床意义
Endocr Rev. 2017 Jun 1;38(3):173-188. doi: 10.1210/er.2016-1146.
2
Association between earlier age at natural menopause and risk of diabetes in middle-aged and older Chinese women: The Dongfeng-Tongji cohort study.绝经年龄早与中国中老年女性糖尿病发病风险的关联：东风-同济队列研究。
Diabetes Metab. 2017 Sep;43(4):345-350. doi: 10.1016/j.diabet.2016.12.011. Epub 2017 Jan 24.
3
Role of Sex Steroids in β Cell Function, Growth, and Survival.性类固醇在β细胞功能、生长和存活中的作用。
Trends Endocrinol Metab. 2016 Dec;27(12):844-855. doi: 10.1016/j.tem.2016.08.008. Epub 2016 Sep 15.
4
Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male.雄激素受体的核外作用增强雄性个体的葡萄糖刺激的胰岛素分泌。
Cell Metab. 2016 May 10;23(5):837-51. doi: 10.1016/j.cmet.2016.03.015. Epub 2016 Apr 28.
5
Oestrogen activity of the serum in adolescents with Type 1 diabetes.1型糖尿病青少年血清中的雌激素活性。
Diabet Med. 2016 Oct;33(10):1366-73. doi: 10.1111/dme.13078. Epub 2016 Feb 12.
6
Estrogen Therapy Delays Autoimmune Diabetes and Promotes the Protective Efficiency of Natural Killer T-Cell Activation in Female Nonobese Diabetic Mice.雌激素疗法可延缓自身免疫性糖尿病，并提高雌性非肥胖糖尿病小鼠中自然杀伤性T细胞激活的保护效率。
Endocrinology. 2016 Jan;157(1):258-67. doi: 10.1210/en.2015-1313. Epub 2015 Oct 20.
7
Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012.美国成年人糖尿病患病率及趋势（1988 年至 2012 年）。
JAMA. 2015 Sep 8;314(10):1021-9. doi: 10.1001/jama.2015.10029.
8
The role of androgens in metabolism, obesity, and diabetes in males and females.雄激素在男性和女性代谢、肥胖和糖尿病中的作用。
Obesity (Silver Spring). 2015 Apr;23(4):713-9. doi: 10.1002/oby.21033. Epub 2015 Mar 6.
9
Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: the BLAST study.睾酮替代疗法可改善 2 型糖尿病伴性腺功能减退症男性的代谢参数，但不能改善合并抑郁症男性的代谢参数：BLAST 研究。
J Sex Med. 2014 Mar;11(3):840-56. doi: 10.1111/jsm.12404. Epub 2013 Dec 6.
10
Bilateral oophorectomy and the risk of incident diabetes in postmenopausal women.双侧卵巢切除术与绝经后妇女新发糖尿病的风险。
Diabetes Care. 2014;37(3):725-33. doi: 10.2337/dc13-1986. Epub 2013 Nov 5.
Zotero 插件