[长链非编码RNA在非酒精性脂肪性肝病中的表达谱]
[Expression profile of long non-coding RNA in non-alcoholic fatty liver disease].
作者信息
Sun Chuanzheng, Huang Feizhou, Yan Wenguang, Liu Huaizheng, Wang Changfa
机构信息
Emergency Department, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Department of Hepatic Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Jul 28;42(7):741-748. doi: 10.11817/j.issn.1672-7347.2017.07.001.
To analyze the characteristics of long non-coding RNA (lncRNA) expression in non-alcoholic fatty liver disease (NAFLD). Methods: lncRNA-mRNA microarray was conducted on the liver tissue samples from 10 patients with simple gallbladder stone (5 NAFLD liver samples and 5 normal liver samples), and the differentially expressed lncRNA was analyzed by bioinformatics technology. Results: Compared with the normal liver samples, there were abnormal expression of 1 735 lncRNAs and 1 485 mRNAs in NAFLD liver samples. Among them, 535 lncRNAs and 760 mRNAs were up-regulated, 1 200 lncRNAs and 725 mRNAs were down-regulated. Conclusion: Compared with normal liver, the expression of lncRNA in NAFLD tissues is obviously abnormal. These lncRNAs may play an important role in the occurrence and development of NAFLD.
分析非酒精性脂肪性肝病（NAFLD）中长链非编码RNA（lncRNA）的表达特征。方法：对10例单纯胆囊结石患者的肝组织样本（5例NAFLD肝样本和5例正常肝样本）进行lncRNA-mRNA微阵列检测，采用生物信息学技术分析差异表达的lncRNA。结果：与正常肝样本相比，NAFLD肝样本中有1735个lncRNA和1485个mRNA表达异常。其中，535个lncRNA和760个mRNA上调，1200个lncRNA和725个mRNA下调。结论：与正常肝脏相比，NAFLD组织中lncRNA的表达明显异常。这些lncRNA可能在NAFLD的发生发展中起重要作用。
Zotero 插件