Buchsbaum M S, Wu J, Haier R, Hazlett E, Ball R, Katz M, Sokolski K, Lagunas-Solar M, Langer D
Life Sci. 1987 Jun 22;40(25):2393-400. doi: 10.1016/0024-3205(87)90753-3.
Patients with generalized anxiety disorder (n = 18) entered a 21-day, double-blind, placebo-controlled random assignment trial of clorazepate. Positron emission tomography with 18F-deoxyglucose was carried out before and after treatment. Decreases in glucose metabolic rate in visual cortex and relative increases in the basal ganglia and thalamus were found. A correlation between regional changes in metabolic rate and regional benzodiazepine receptor binding density from other human autopsy studies was observed; brain regions highest in receptor density showed the greatest decrease in rate.
