1 Tecnologico de Monterrey, Escuela de Medicina Y Ciencias de la Salud, Monterrey, Mexico .
2 Internal Medicine Department, SSNL-Hospital Metropolitano "Dr. Bernardo Sepúlveda ," Monterrey, Mexico .
J Palliat Med. 2018 Feb;21(2):163-168. doi: 10.1089/jpm.2017.0043. Epub 2017 Aug 28.
Palliative care is an evolving but underdeveloped practice in Mexico.
The primary end point of this prospective observational study was to identify internal medicine inpatients fulfilling advanced criteria within a second-level hospital. Secondary end points were symptom burden, treatment, resource utilization, and one-year survival.
The 390-sample size calculation was based on previous studies where 15% of inpatients fulfilled palliative care needs. Consecutive admissions were assessed to identify patients with any of the following: cancer, cardiac, renal, hepatic insufficiency, COPD, AIDS, stroke, or fragility until sample size was completed. After obtaining informed consent, interview to patient, attending physician, and chart review was completed to identify any of the following advanced disease criteria in each patient: (1) Surprise question to attending physician of the possibility of the patient dying in the following year, (2) Palliative Performance Scale (PPS) <50, and (3) Advanced disease specific criteria. Interview also included presence of symptoms, functional capacity, and previous resource utilization. Treatment offered was analyzed only on day of admission. One-year follow-up to assess survival was done through the state death certificates.
Out of 390 patients, 131 (34%) had any of the diseases studied. Out of 131 patients, 86 (66%) had at least one of the three inclusion criteria for advanced disease. Out of 86 patients, 70 (81%) advanced disease patients died after one-year follow-up. Comparison between patients with no advanced disease (no criteria) versus advanced disease (at least one criteria) showed a significant difference in mean PPS, nutrition status, survival days, inhospital death, weight loss, dependency on activities of daily living, and previous multiple emergency room visits. Advanced disease patients with no death at one year follow-up had significantly more new admissions to that hospital.
The number of patients requiring palliative care in internal medicine wards may be excessive to the current palliative care structures available.
缓和医疗在墨西哥是一种不断发展但尚未充分发展的实践。
本前瞻性观察研究的主要终点是在二级医院确定符合高级标准的内科住院患者。次要终点是症状负担、治疗、资源利用和一年生存率。
根据之前的研究,15%的住院患者需要姑息治疗,因此进行了 390 例样本量的计算。连续评估入院患者,以确定以下任何一种患者:癌症、心脏病、肾功能不全、肝功能不全、COPD、艾滋病、中风或脆弱性,直到完成样本量。获得知情同意后,对患者、主治医生和病历进行访谈和回顾,以确定每位患者是否存在以下任何一种晚期疾病标准:(1)主治医生对患者在接下来一年死亡可能性的意外问题,(2)姑息治疗表现量表(PPS)<50,和(3)晚期疾病具体标准。访谈还包括症状、功能能力和以前的资源利用情况。仅在入院当天分析提供的治疗方法。通过州死亡证明进行为期一年的随访,以评估生存情况。
在 390 名患者中,有 131 名(34%)患有研究中的任何一种疾病。在 131 名患者中,有 86 名(66%)至少有三种晚期疾病纳入标准中的一种。在 86 名患者中,有 70 名(81%)晚期疾病患者在一年随访后死亡。无晚期疾病(无标准)患者与晚期疾病(至少有一个标准)患者比较,在平均 PPS、营养状况、生存天数、院内死亡、体重减轻、日常生活活动依赖和以前多次急诊就诊方面有显著差异。在一年随访时无死亡的晚期疾病患者有更多人再次入住该医院。
内科病房需要姑息治疗的患者数量可能超过当前姑息治疗结构的能力。