Boemer François, Detilleux Johann, Cello Christophe, Amory Hélène, Marcillaud-Pitel Christel, Richard Eric, van Galen Gaby, van Loon Gunther, Lefère Laurence, Votion Dominique-Marie
Biochemical Genetics Laboratory, CHU Sart Tilman, University of Liege, Liege, Belgium.
Department of animal Productions: Biostatistics, Economy and animal selection, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liege, Belgium.
PLoS One. 2017 Aug 28;12(8):e0182761. doi: 10.1371/journal.pone.0182761. eCollection 2017.
Equine atypical myopathy (AM) is caused by hypoglycin A intoxication and is characterized by a high fatality rate. Predictive estimation of survival in AM horses is necessary to prevent unnecessary suffering of animals that are unlikely to survive and to focus supportive therapy on horses with a possible favourable prognosis of survival. We hypothesized that outcome may be predicted early in the course of disease based on the assumption that the acylcarnitine profile reflects the derangement of muscle energetics. We developed a statistical model to prognosticate the risk of death of diseased animals and found that estimation of outcome may be drawn from three acylcarnitines (C2, C10:2 and C18 -carnitines) with a high sensitivity and specificity. The calculation of the prognosis of survival makes it possible to distinguish the horses that will survive from those that will die despite severe signs of acute rhabdomyolysis in both groups.
马属动物非典型肌病（AM）由低血糖素A中毒引起，具有高致死率的特点。对AM马匹的生存进行预测性评估，对于防止不太可能存活的动物遭受不必要的痛苦以及将支持性治疗集中于可能有良好生存预后的马匹至关重要。我们假设，基于酰基肉碱谱反映肌肉能量代谢紊乱这一假设，疾病过程早期可能就能预测结果。我们开发了一个统计模型来预测患病动物的死亡风险，发现可以从三种酰基肉碱（C2、C10:2和C18 -肉碱）得出结果估计，其具有高敏感性和特异性。生存预后的计算使得区分两组中尽管有严重急性横纹肌溶解体征但仍将存活的马匹和将会死亡的马匹成为可能。
