Schreiber V, Pribyl T, Jahodová J
Physiol Bohemoslov. 1982;31(2):97-100.
The increase in adenohypophyseal weight and the decrease in the ascorbic acid concentration in the hypothalamus of rats injected i.m. twice a week with oestradiol benzoate as an aqueous microcrystal suspension in doses of 2.65 mumol (1 mg) was completely (HAA) or almost completely (adenohypophyseal weight) inhibited by the simultaneous administration of the ergoline derivative D-6-methyl-8-ergoline-(1)-yl acetic acid amide (Deprenon SPOFA) in the diet in daily doses of 0.28 mumol (200 micrograms) per rat. The functional significance of HAA in dopaminergic modulation of oestrogen-induced adenohypophyseal growth is discussed, with special reference to the possible function of HAA as a dopamine-beta-hydroxylase cofactor.
每周两次肌肉注射剂量为2.65微摩尔（1毫克）的苯甲酸雌二醇水微晶悬液，会使大鼠腺垂体重量增加，下丘脑抗坏血酸浓度降低。而每日在饮食中给每只大鼠投喂0.28微摩尔（200微克）的麦角灵衍生物D-6-甲基-8-麦角灵-（1）-基乙酸酰胺（Deprenon SPOFA），可完全抑制（抗坏血酸），或几乎完全抑制（腺垂体重量）上述变化。文中讨论了抗坏血酸在雌激素诱导的腺垂体生长的多巴胺能调节中的功能意义，特别提及了抗坏血酸作为多巴胺-β-羟化酶辅因子的可能功能。
