硝酸银对雌二醇作用的调节：抑制腺垂体反应、阻断血浆铜蓝蛋白增加以及阻断下丘脑抗坏血酸消耗。
Modulation oestradiol effects by silver nitrate: inhibition of the adenohypophyseal reaction, block of the ceruloplasmin increase and block of hypothalamic ascorbic acid depletion.
作者信息
Schreiber V, Pribyl T, Jahodová J
出版信息
Endokrinologie. 1980 Oct;76(2):129-36.
Chronic oestradiol treatment (1 mg oestradiol benzoate, as an aqueous microcrystal suspension, i.m. twice a week for 6 weeks) produces in rats increased thyroxine-binding capacity of the adenohypophyseal proteins in vitro, an increase in the ceruloplasmin (polyphenol oxidase) level in blood and a decrease in the hypothalamic ascorbic acid concentration. The simultaneous administration of silver nitrate (10mg/rat/day in food) inhibits all these reactions in oestradiol. Apart from inhibiting blood polyphenol oxidase activity, silver nitrate itself has no effect. The possibility of the interaction of polyphenol oxidase(ceruloplasmin), silver nitrate and hypothalamic ascorbic acid in the dopaminergic modulation of the adenohypophyseal reaction to oestradiol is discussed.
慢性雌二醇治疗（1毫克苯甲酸雌二醇，以水性微晶悬浮液形式，每周两次肌肉注射，共6周）可使大鼠腺垂体蛋白质的甲状腺素结合能力在体外增加，血液中铜蓝蛋白（多酚氧化酶）水平升高，下丘脑抗坏血酸浓度降低。同时给予硝酸银（食物中10毫克/大鼠/天）可抑制雌二醇引起的所有这些反应。除了抑制血液中的多酚氧化酶活性外，硝酸银本身无作用。本文讨论了多酚氧化酶（铜蓝蛋白）、硝酸银和下丘脑抗坏血酸在腺垂体对雌二醇反应的多巴胺能调节中的相互作用可能性。
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