多巴胺能对腺垂体对雌二醇反应的调节：奋乃静与甲状腺激素的相互作用。
Dopaminergic modulation of the adenohypophyseal reaction to oestradiol: interaction of perphenazine with the thyroid hormones.
作者信息
Schreiber V, Pribyl T, Jahodová J
出版信息
Physiol Bohemoslov. 1980;29(2):173-9.
In male and female rats, oestradiol raises adenohypophyseal weight, the thyroxine-binding capacity of the adenohypophyseal proteins and the blood ceruloplasmin (polyphenol oxidase) level and reduces the ascorbic acid concentration in the hypothalamus. Simultaneous administration of the thyroid hormones inhibits all these reactions. The simultaneous administration of perphenazine (a dopaminergic neurone inhibitor) potentiates the adenohypophyseal and ceruloplasmin reaction, but does not modify the hypothalamic ascorbic acid reaction. Perphenazine combined with the thyroid hormones blocks the latters' inhibitory effect on the adenohypophyseal, ceruloplasmin and hypothalamic ascorbic acid reaction to oestradiol. The possible mechanisms by which perphenazine blocks the inhibitory effect of the thyroid hormones are discussed.
在雄性和雌性大鼠中，雌二醇会增加腺垂体重量、腺垂体蛋白质的甲状腺素结合能力以及血液铜蓝蛋白（多酚氧化酶）水平，并降低下丘脑的抗坏血酸浓度。同时给予甲状腺激素会抑制所有这些反应。同时给予奋乃静（一种多巴胺能神经元抑制剂）会增强腺垂体和铜蓝蛋白反应，但不会改变下丘脑抗坏血酸反应。奋乃静与甲状腺激素联合使用会阻断后者对腺垂体、铜蓝蛋白和下丘脑抗坏血酸对雌二醇反应的抑制作用。文中讨论了奋乃静阻断甲状腺激素抑制作用的可能机制。
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