Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Antimicrob Agents Chemother. 2017 Oct 24;61(11). doi: 10.1128/AAC.01056-17. Print 2017 Nov.
We determined the interactions between echinocandins and azoles against 10 multidrug-resistant strains by use of a microdilution checkerboard technique. Our results suggest synergistic interactions between micafungin and voriconazole with fractional inhibitory concentration index (FICI) values of 0.15 to 0.5, and we observed indifferent interactions when micafungin was combined with fluconazole (FICI, 0.62 to 1.5). Combinations of caspofungin with fluconazole or voriconazole exhibited indifferent interactions. No antagonism was observed for any combination.
我们使用微量稀释棋盘技术确定了棘白菌素类药物和唑类药物对 10 株多药耐药菌株的相互作用。我们的结果表明，米卡芬净与伏立康唑之间存在协同作用，其部分抑菌浓度指数（FICI）值为 0.15 至 0.5，而米卡芬净与氟康唑联合使用时则表现为无关作用（FICI 值为 0.62 至 1.5）。卡泊芬净与氟康唑或伏立康唑联合使用时表现为无关作用。任何组合均未观察到拮抗作用。
