Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
Department of Physiology, Faculty of Biology, University of Szczecin, Felczaka 3c, 71-412, Szczecin, Poland.
Stem Cell Rev Rep. 2017 Dec;13(6):774-780. doi: 10.1007/s12015-017-9763-z.
Umbilical cord blood (UCB) is a rich source of stem cells, including hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), endothelial progenitors cells (EPCs), and very small embryonic-like stem cells (VSELs). These cells most likely are mobilized into UCB in response to hypoxia and delivery stress. We have hypothesized that they may play a role in repairing certain tissue/organ injuries that occur in the newborn child after delivery. Here we asked whether delivery also mobilizes stem cells into maternal blood, as the mother also experiences hypoxia and several types of internal tissue injuries, particularly in the reproductive tract. We observed that the number of HSCs, MSCs, EPCs, and VSELs increases in maternal blood at 24 h after physiological delivery (n = 17). Based on this observation, we propose that delivery stress is associated with an increase in the number of circulating stem cells, not only on the fetal side but also on the maternal side of the fetal-maternal circulatory barrier.
脐带血（UCB）是干细胞的丰富来源，包括造血干细胞（HSCs）、间充质干细胞（MSCs）、内皮祖细胞（EPCs）和非常小的胚胎样干细胞（VSELs）。这些细胞很可能是对缺氧和分娩应激做出反应而动员到 UCB 中的。我们假设它们可能在修复新生儿出生后发生的某些组织/器官损伤方面发挥作用。在这里，我们询问分娩是否也会将干细胞动员到母体血液中，因为母亲也会经历缺氧和几种类型的内部组织损伤，特别是在生殖道。我们观察到，在生理分娩后 24 小时，母体血液中的 HSCs、MSCs、EPCs 和 VSELs 数量增加（n=17）。基于这一观察结果，我们提出分娩应激与循环干细胞数量的增加有关，不仅在胎儿侧，而且在胎儿-母体循环屏障的母体侧。
