Piechnik Stefan K, Jerosch-Herold Michael
Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX39DU, UK.
Brigham and Women's Hospital, and Harvard Medical School, 15 Francis Street, Boston, MA, 02115, USA.
Int J Cardiovasc Imaging. 2018 Jan;34(1):3-14. doi: 10.1007/s10554-017-1235-7. Epub 2017 Aug 28.
Novel tissue biomarkers based on the spin-lattice relaxation time T1, a fundamental property in the theory of magnetic resonance physics, have emerged as a new approach for myocardial tissue characterization with many validated clinical applications. This article is intended as an overview of the physical and physiological mechanisms underlying the interpretation and the accuracy of any practical measurement of T1, or derived biomarkers such as extravascular volume fraction, and also includes a discussion of potential pitfalls. Numerous caveats und knowledge gaps related to the precise interpretation of T1-based biomarkers remain, which are being addressed incrementally through ongoing research. Equally important, further careful standardization will pave the way for a wider clinical translation of these novel T1-based biomarkers of tissue remodeling, which have been well validated for their sensitivity to pathophysiological changes, though for the most part in single-center studies.
基于自旋晶格弛豫时间T1的新型组织生物标志物已成为心肌组织特征分析的一种新方法，并在许多临床应用中得到验证。T1是磁共振物理理论中的一个基本属性。本文旨在概述T1实际测量及其衍生生物标志物（如血管外容积分数）的解释和准确性背后的物理和生理机制，并讨论潜在的陷阱。与基于T1的生物标志物的精确解释相关的众多注意事项和知识空白仍然存在，目前正在通过持续研究逐步解决。同样重要的是，进一步仔细的标准化将为这些基于T1的新型组织重塑生物标志物的更广泛临床应用铺平道路。尽管在大多数单中心研究中，这些生物标志物对病理生理变化的敏感性已得到充分验证。
