Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu, 550-749, South Korea.
Division of Food Bioscience and Korea Nokyong Research Center, Konkuk University, Chungju, 27478, South Korea.
Adv Exp Med Biol. 2017;975 Pt 2:931-942. doi: 10.1007/978-94-024-1079-2_74.
Mussel (Mytilus coruscus) water extract had strong anti-inflammatory activities, but the effects and its mechanisms of mussel on anti-inflammatory properties in vivo remain to be determined. This study, therefore, was designed to investigate anti-inflammatory activities of mussel water extract containing a large amounts of taurine (151.96 nmol/mg) using the lipopolysaccharide (LPS)-induced inflammatory zebrafish model. In this study, mussel water extract containing taurine shows potent protective effects against the cell death stimulated by LPS exposure in zebrafish embryos. In addition, zebrafish subjected to LPS treatment exhibited significantly increased reactive oxygen species (ROS) and nitric oxide (NO) levels. However, mussel water extract markedly suppressed LPS-induced ROS and NO production. Our results indicate that mussel water extract attenuated inflammation by inhibiting the LPS-induced intracellular ROS and NO production in zebrafish embryos. These findings could demonstrate the anti-inflammatory activity of mussel water extract containing taurine, which might have a protective effects on inflammatory diseases.
贻贝（贻贝）水提取物具有很强的抗炎活性，但贻贝对体内抗炎特性的影响及其机制仍有待确定。因此，本研究旨在使用脂多糖（LPS）诱导的炎症斑马鱼模型研究含有大量牛磺酸（151.96 nmol / mg）的贻贝水提取物的抗炎活性。在这项研究中，含有牛磺酸的贻贝水提取物显示出对斑马鱼胚胎中由 LPS 暴露刺激的细胞死亡的有效保护作用。此外，用 LPS 处理的斑马鱼表现出活性氧（ROS）和一氧化氮（NO）水平显着增加。然而，贻贝水提取物明显抑制了 LPS 诱导的 ROS 和 NO 的产生。我们的研究结果表明，贻贝水提取物通过抑制斑马鱼胚胎中 LPS 诱导的细胞内 ROS 和 NO 的产生来减轻炎症。这些发现可以证明含有牛磺酸的贻贝水提取物的抗炎活性，这可能对炎症性疾病具有保护作用。
